Traf6 Gene Summary [Mouse]
This gene encodes a member of the TNF receptor associated factor (TRAF) family of adaptor proteins that mediate signaling events from members of the TNF receptor and Toll/IL-1 receptor families to activate transcription factors such as NF-kappa-B and AP-1. The product of this gene is essential for perinatal and postnatal survival. Mice deficient in this protein exhibit osteopetrosis and defective in development of epidermal appendixes, normal B cell differentiation, lymph node organogenesis, interleukin-1 signaling, lipopolysaccharide signaling and neural tube closure. This protein possesses ubiquitin ligase activity. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Details
| Type | Processed Transcript |
| Official Symbol | Traf6 |
| Official Name | TNF receptor-associated factor 6 [Source:MGI Symbol;Acc:MGI:108072] |
| Ensembl ID | ENSMUSG00000027164 |
| Bio databases IDs | |
| Aliases | TNF receptor-associated factor 6 |
| Synonyms | 2310003F17Rik, C630032O20Rik, LOC100042930, LOC100048242, MGC:3310, RNF85, TNF receptor-associated factor 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Traf6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- coiled-coil domain
- enzyme
- identical protein binding
- TRAF-type zinc finger
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- TRAF-like zinc-finger
- CART domain
- protein kinase binding
- MATH
- zinc finger of C3HC4-type, RING
- ubiquitin protein ligase activity
- TRAF-N subdomain
- enzyme binding
- histone deacetylase binding
- Ring finger domain
- protein binding
- TRAF domain
- TNF receptor-associated factor 6 zinc finger 2
- RING-type zinc-finger
- Modified RING finger domain
- ubiquitin-protein transferase activity
- zinc finger domain
- TRAF-C subdomain
- Zinc finger, C3HC4 type (RING finger)
Pathways
Biological processes and signaling networks where the Traf6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Acute Phase Response Signaling
- April Mediated Signaling
- Autophagy
- B Cell Activating Factor Signaling
- CD40 Signaling
- Dendritic Cell Maturation
- Glucocorticoid Receptor Signaling
- Hepatic Cholestasis
- IL-1 Signaling
- IL-10 Signaling
- IL-12 Signaling and Production in Macrophages
- IL-17 Signaling
- IL-17A Signaling in Airway Cells
- IL-17A Signaling in Fibroblasts
- IL-6 Signaling
- IL-8 Signaling
- iNOS Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- Lymphotoxin β Receptor Signaling
- NF-κB Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- fibrosis
- glioma formation
- glioma
- dextran sodium sulfate-induced colitis
- lipopolysaccharide-induced lung injury
- osteopetrosis
- Churg-Strauss syndrome
- exencephaly
- neurological deficiency
phenotypes
- increased grip strength
- preweaning lethality complete penetrance
- abnormal Meibomian gland development
- abnormal Mullerian duct morphology
- abnormal Wolffian duct morphology
- abnormal brain commissure morphology
- abnormal brain morphology
- abnormal coat/ hair morphology
- abnormal coronary sinus connection
- abnormal dendritic cell differentiation
- abnormal dendritic cell physiology
- abnormal ductus venosus valve topology
- abnormal endolymphatic sac topology
- abnormal eye muscle morphology
- abnormal forebrain morphology
- abnormal hair follicle development
- abnormal kidney morphology
- abnormal long bone metaphysis morphology
- abnormal long bone morphology
- abnormal lymph node morphology
- abnormal macrophage physiology
- abnormal male preputial gland morphology
- abnormal myocardium compact layer morphology
- abnormal olfactory bulb morphology
- abnormal optic cup morphology
- abnormal optic stalk morphology
- abnormal osteoclast differentiation
- abnormal osteoclast morphology
- abnormal osteoclast physiology
- abnormal sebaceous gland morphology
- abnormal skin pigmentation
- abnormal spleen morphology
- abnormal stapes morphology
- abnormal vertebral artery topology
- abnormal vitelline vein topology
- absent ductus venosus valve
- absent eccrine glands
- absent guard hair
- absent incisors
- absent molars
- absent spleen white pulp
- absent stapedial artery
- alopecia
- bifid ureter
- blood in lymph vessels
- decreased B cell proliferation
- decreased body length
- decreased body size
- decreased body weight
- decreased bone resorption
- decreased circulating phosphate level
- decreased dendritic cell number
- decreased immature B cell number
- decreased interleukin-12 secretion
- decreased interleukin-6 secretion
- decreased length of long bones
- decreased lymph node number
- decreased survivor rate
- decreased tumor necrosis factor secretion
- dilated bile duct
- ductus venosus stenosis
- enlarged heart
- enlarged liver
- enlarged spleen
- exencephaly
- failure of tooth eruption
- herniated liver
- hypochromic anemia
- increased bone mineral density
- intestinal/bowel diverticulum
- kinked tail
- multiple persisting craniopharyngeal ducts
- muscular ventricular septal defect
- osteopetrosis
- perimembraneous ventricular septal defect
- perinatal lethality incomplete penetrance
- persistent right 6th pharyngeal arch artery
- persistent right dorsal aorta
- postnatal growth retardation
- postnatal lethality complete penetrance
- postnatal lethality incomplete penetrance
- preweaning lethality incomplete penetrance
- short femur
- small perianal sebaceous gland
- subcutaneous edema
- thin hypoglossal nerve
- thymus atrophy
- translucent skin
- umbilical vein stenosis
role in cell
- expression in
- proliferation
- phosphorylation in
- activation in
- tyrosine phosphorylation in
- number
- migration
- production in
- cell death
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- membrane fraction
- glutaminergic synapse
- perinuclear region
- postsynaptic region
- cellular membrane
- Nucleus
- Plasma Membrane
- lipid droplets
- cytosol
- cytoplasmic face of plasma membrane
- endosomal membrane
- nucleoplasm
- nuclear envelope
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Traf6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of JUN kinase activity
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of NF-kappaB transcription factor activity
- cytoplasmic pattern recognition receptor signaling pathway
- MyD88-dependent toll-like receptor signaling pathway
- positive regulation of transcription regulatory region DNA binding
- negative regulation of transcription, DNA-dependent
- in utero embryonic development
- bone resorption
- ossification
- regulation of immunoglobulin production
- positive regulation of protein ubiquitination
- antigen processing and presentation of exogenous peptide antigen via MHC class II
- positive regulation of type I interferon production
- toll-like receptor 4 signaling pathway
- NIK/NF-kappaB cascade
- regulation of apoptotic process
- positive regulation of T cell proliferation
- response to DNA damage stimulus
- tumor necrosis factor-mediated signaling pathway
- positive regulation of T cell cytokine production
- response to interleukin-1
- toll-like receptor 3 signaling pathway
- lipopolysaccharide-mediated signaling pathway
- positive regulation of interleukin-6 production
- positive regulation of lipopolysaccharide-mediated signaling pathway
- TRIF-dependent toll-like receptor signaling pathway
- Fc-epsilon receptor signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of I-kappaB kinase/NF-kappaB cascade
- odontogenesis of dentin-containing tooth
- positive regulation of transcription from RNA polymerase II promoter
- stimulatory C-type lectin receptor signaling pathway
- autophagic vacuole assembly
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of osteoclast differentiation
- neural tube closure
- myeloid dendritic cell differentiation
- activation of protein kinase activity
- T cell receptor signaling pathway
- positive regulation of interleukin-2 production
- protein autoubiquitination
- protein polyubiquitination
- T-helper 1 type immune response
- I-kappaB kinase/NF-kappaB cascade
- osteoclast differentiation
- positive regulation of interleukin-12 production
- cellular response to lipopolysaccharide
- innate immune response
- protein K63-linked ubiquitination
- cellular response to cytokine stimulus
- interleukin-1-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- internal side of plasma membrane
- lipid particle
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cell cortex
- cytosol
- extrinsic to internal side of plasma membrane
- endosome membrane
- macromolecular complex
- CD40 receptor complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- identical protein binding
- zinc ion binding
- ubiquitin conjugating enzyme binding
- protein binding
- histone deacetylase binding
- ubiquitin-ubiquitin ligase activity
- tumor necrosis factor receptor binding
- protein kinase B binding