Cyp7a1 Gene Summary [Mouse]
Enables cholesterol 7-alpha-monooxygenase activity. Acts upstream of or within cholesterol catabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in liver. Orthologous to human CYP7A1 (cytochrome P450 family 7 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp7a1 |
| Official Name | cytochrome P450, family 7, subfamily a, polypeptide 1 [Source:MGI Symbol;Acc:MGI:106091] |
| Ensembl ID | ENSMUSG00000028240 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 7, subfamily a, polypeptide 1 |
| Synonyms | 7-α Hydroxylase, C7 α h, CHAP, cholesterol 7alpha-hydroxylase, Cholesterol7 α Hydroxylase, Cholesterol hydroxylase 7 α, CP7A, CYP7, CYP7A, CYP7S1, CYPVII, CYPVIIc, cytochrome P450 family 7 subfamily A member 1, cytochrome P450, family 7, subfamily a, polypeptide 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cyp7a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- cholesterol 7alpha-monooxygenase
- enzyme
Pathways
Biological processes and signaling networks where the Cyp7a1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- progressive familial intrahepatic cholestasis type 1
- cholelithiasis
- progressive familial intrahepatic cholestasis type 2
- cerebrotendinous xanthomatosis
- steatorrhea
- nonalcoholic steatohepatitis
- dermatological disorder
- hyperkeratosis
- dry skin
phenotypes
- abnormal lens morphology
- abnormal retina morphology
- abnormal retinal vasculature morphology
- cataract
- decreased blood urea nitrogen level
- decreased circulating iron level
- decreased circulating serum albumin level
- decreased mean corpuscular volume
- increased circulating HDL cholesterol level
- increased circulating alkaline phosphatase level
- increased circulating amylase level
- increased circulating cholesterol level
- increased circulating unsaturated transferrin level
- increased leukocyte cell number
- increased startle reflex
- abnormal bile composition
- abnormal bile salt homeostasis
- abnormal bile salt level
- abnormal blood urea nitrogen level
- abnormal circulating HDL cholesterol level
- abnormal circulating alkaline phosphatase level
- abnormal circulating amylase level
- abnormal circulating cholesterol level
- abnormal circulating iron level
- abnormal epidermis stratum basale morphology
- abnormal epidermis stratum granulosum morphology
- abnormal fat-soluble vitamin level
- abnormal leukocyte cell number
- abnormal lipid homeostasis
- abnormal liver morphology
- abnormal liver physiology
- abnormal skin condition
- abnormal skin morphology
- abnormal startle reflex
- abnormal vision
- decreased birth weight
- decreased exploration in new environment
- decreased intestinal cholesterol absorption
- delayed eyelid opening
- dry skin
- flaky skin
- greasy coat
- hyperkeratosis
- hypoactivity
- oily skin
- perinatal lethality incomplete penetrance
- postnatal growth retardation
- postnatal lethality incomplete penetrance
- steatorrhea
- thin dermal layer
- thin epidermis stratum spinosum
role in cell
- expression in
- apoptosis
- response by
- infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- endoplasmic reticulum membrane
- smooth endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cyp7a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of fatty acid biosynthetic process
- positive regulation of cholesterol biosynthetic process
- bile acid biosynthetic process
- cholesterol homeostasis
- response to ethanol
- negative regulation of collagen biosynthetic process
- cholesterol catabolic process
- cellular response to glucose stimulus
- cellular response to cholesterol
- regulation of bile acid biosynthetic process
- sterol metabolic process
- bile acid and bile salt transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- intracellular membrane-bounded organelle
Molecular Function
What the gene product does at the molecular level
- 24-hydroxycholesterol 7alpha-hydroxylase activity
- iron ion binding
- cholesterol 7-alpha-monooxygenase activity
- heme binding