Cdh5 Gene Summary [Mouse]
This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Mice lacking the encoded protein die in utero due to vascular insufficiency, caused by increased endothelial apoptosis. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Oct 2015]
Details
| Type | Protein Coding |
| Official Symbol | Cdh5 |
| Official Name | cadherin 5 [Source:MGI Symbol;Acc:MGI:105057] |
| Ensembl ID | ENSMUSG00000031871 |
| Bio databases IDs | |
| Aliases | cadherin 5 |
| Synonyms | 7B4, AA408225, cadherin 5, CD144, Vec, VE-Cad, Ve Cad2, VE-CADHERIN, VECD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdh5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-catenin binding domain
- extracellular domain
- protein kinase binding
- beta-catenin binding
- cell adhesion molecule binding
- protein phosphatase binding
- ectodomain
- RGD motif
- protein binding
- receptor binding
- vascular endothelial growth factor receptor binding
- p120-catenin binding domain
- Cadherin, Y-type LIR-motif
- binding protein
- cytoplasmic domain
- receptor signaling complex scaffold protein
- transmembrane domain
- Cadherin repeat-like domain
- ion channel binding
- catenin binding domain
- cytosolic tail domain
- membrane-proximal domain
- extracellular cadherin structural domain
Pathways
Biological processes and signaling networks where the Cdh5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bleeding
- growth failure
- Alzheimer disease
- edema
- arterial aneurysm and dissection
- Klinefelter syndrome
- preeclampsia
- vascular leak syndrome
- diffuse systemic sclerosis
phenotypes
- abnormal angiogenesis
- abnormal cardiac outflow tract development
- abnormal cell death
- abnormal cellular extravasation
- abnormal common myeloid progenitor cell morphology
- abnormal definitive hematopoiesis
- abnormal hematopoietic precursor cell number
- abnormal hematopoietic stem cell physiology
- abnormal intersomitic vessel morphology
- abnormal leukocyte migration
- abnormal lymphatic vessel endothelial cell morphology
- abnormal lymphatic vessel endothelium morphology
- abnormal lymphatic vessel morphology
- abnormal ovary morphology
- abnormal placenta vasculature
- abnormal skin physiology
- abnormal somite development
- abnormal umbilical artery morphology
- abnormal umbilical cord blood vessel morphology
- abnormal uterus morphology
- abnormal vascular development
- abnormal vascular endothelial cell development
- abnormal vascular endothelial cell morphology
- abnormal vascular permeability
- abnormal vasculogenesis
- abnormal vein development
- abnormal visceral yolk sac blood island morphology
- abnormal vitelline vasculature morphology
- absent vitelline blood vessels
- decreased angiogenesis
- decreased liver weight
- decreased vascular permeability
- delayed heart development
- dilated dorsal aorta
- distended pericardium
- edema
- embryonic growth arrest
- embryonic growth retardation
- embryonic lethality during organogenesis complete penetrance
- embryonic lethality during organogenesis incomplete penetrance
- embryonic lethality complete penetrance
- enlarged endometrial glands
- enlarged ovary
- enlarged uterus
- impaired neutrophil recruitment
- incomplete embryo turning
- incomplete somite formation
- increased apoptosis
- increased leukocyte cell number
- increased neutrophil cell number
- increased vascular permeability
- irregular heartbeat
- lethality throughout fetal growth and development complete penetrance
- liver hypoplasia
- lymphedema
- no abnormal phenotype detected
- ovarian follicular cyst
- ovary cysts
- ovary fibrosis
- pallor
- preweaning lethality incomplete penetrance
- small liver
- small pharyngeal arch
- uterus fibrosis
- uterus hypertrophy
role in cell
- expression in
- apoptosis
- binding
- proliferation
- survival
- quantity
- differentiation
- paracellular permeability
- organization
- transmigration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- membrane fraction
- zipper-like junction
- button-like junction
- apical ectoplasmic specialization
- cell junction
- Cytoplasm
- cell surface
- cell borders
- cell periphery
- cellular membrane
- intercellular junctions
- desmosomes
- hemidesmosomes
- endothelial paracellular clefts
- cell-cell contacts
- cytoplasmic bridges
- plasma membrane extracellular face
- nucleoplasm
- nuclear envelope
- sperm head
- pedicels
- anchoring junction
- tight junctions
- cell-cell adherens junctions
- plasma
- podocyte slit diaphragm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdh5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adherens junction organization
- multicellular organismal development
- negative regulation of cell proliferation
- transforming growth factor beta receptor signaling pathway
- homophilic cell adhesion
- positive regulation of angiogenesis
- negative regulation of endothelial cell apoptotic process
- cell migration
- positive regulation of protein complex assembly
- maintenance of blood-brain barrier
- negative regulation of microtubule polymerization
- regulation of establishment of cell polarity
- calcium-dependent cell-cell adhesion
- cell-cell junction assembly
- cell morphogenesis
- negative regulation of inflammatory response
- regulation of vascular permeability
- blood vessel endothelial cell migration
- cellular calcium ion homeostasis
- positive regulation of BMP signaling pathway
- regulation of protein phosphorylation
- positive regulation of gene expression
- blood vessel maturation
- cell-cell adhesion mediated by cadherin
- tight junction assembly
- positive regulation of protein dephosphorylation
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- tight junction
- nuclear membrane
- adherens junction
- cell-cell junction
- membrane
- external side of plasma membrane
- cell junction
- catenin complex
- plasma membrane
- nucleoplasm
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein phosphatase binding
- protein binding
- fibrinogen binding
- vascular endothelial growth factor receptor 2 binding
- cadherin binding
- calcium ion binding
- beta-catenin binding
- receptor binding
- ion channel binding
- BMP receptor binding