Cyp19a1 Gene Summary [Mouse]
Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Acts upstream of or within several processes, including negative regulation of macrophage chemotaxis; reproductive structure development; and steroid metabolic process. Predicted to be located in several cellular components, including dendritic spine; neuronal cell body; and synaptic vesicle. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including central nervous system; gonad; gonad primordium; retina; and stomach. Used to study Sjogren's syndrome and aromatase excess syndrome. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; endometriosis (multiple); ovarian disease (multiple); and prostate disease (multiple). Orthologous to human CYP19A1 (cytochrome P450 family 19 subfamily A member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp19a1 |
| Official Name | cytochrome P450, family 19, subfamily a, polypeptide 1 [Source:MGI Symbol;Acc:MGI:88587] |
| Ensembl ID | ENSMUSG00000032274 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 19, subfamily a, polypeptide 1 |
| Synonyms | Ar, ArKO, ARO, ARO1, Aromatase, CPV1, CYAR, CYP19, Cyp19a, CYP19P1, CYPXIX, cytochrome P450 family 19 subfamily A member 1, cytochrome P450, family 19, subfamily a, polypeptide 1, Int-5, LOC100359906, P-450AROM, p450 aromatase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cyp19a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- electron carrier
- oxygen binding
- aromatase
- reduced flavin or flavoprotein:oxygen oxidoreductase
- unspecific monooxygenase
- enzyme
- steroid hydroxylase
- heme binding
Pathways
Biological processes and signaling networks where the Cyp19a1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- neoplasia
- weight gain
- hepatic steatosis
- obesity
- insulin resistance
- hyperglycemia
- invasive breast cancer
- metastatic invasive breast cancer
- malignant neoplasm of endometrium
phenotypes
- decreased circulating alkaline phosphatase level
- decreased exploration in new environment
- decreased large unstained cell number
- decreased lean body mass
- decreased leukocyte cell number
- decreased lymphocyte cell number
- hypoactivity
- increased anxiety-related response
- increased blood urea nitrogen level
- increased circulating cholesterol level
- increased fasting circulating glucose level
- increased total body fat amount
- thrombocytosis
- Leydig cell hyperplasia
- abnormal acrosome morphology
- abnormal adipose tissue amount
- abnormal auditory brainstem response
- abnormal barbering behavior
- abnormal baroreceptor physiology
- abnormal bone trabecula morphology
- abnormal circulating alkaline phosphatase level
- abnormal circulating cholesterol level
- abnormal coat/hair pigmentation
- abnormal compact bone morphology
- abnormal copulation
- abnormal emotion/affect behavior
- abnormal enzyme/coenzyme level
- abnormal epididymis morphology
- abnormal exploration in a new environment
- abnormal glucose homeostasis
- abnormal labium morphology
- abnormal lean body mass
- abnormal lipid homeostasis
- abnormal liver lobule morphology
- abnormal liver physiology
- abnormal locomotor activation
- abnormal male germ cell apoptosis
- abnormal male germ cell morphology
- abnormal male reproductive system morphology
- abnormal mating frequency
- abnormal mature ovarian follicle morphology
- abnormal ovarian follicle morphology
- abnormal ovary morphology
- abnormal parental behavior
- abnormal primary sex determination
- abnormal prostate gland physiology
- abnormal reproductive system physiology
- abnormal salivary gland morphology
- abnormal seminiferous tubule epithelium morphology
- abnormal seminiferous tubule morphology
- abnormal sexual interaction
- abnormal short term spatial reference memory
- abnormal spermatid morphology
- abnormal spermatogenesis
- abnormal spermiogenesis
- abnormal spleen germinal center morphology
- abnormal systemic arterial blood pressure
- abnormal trabecular bone morphology
- abnormal uterus development
- abnormal white adipose tissue morphology
- absent corpus luteum
- absent ovarian follicles
- anovulation
- arrest of spermiogenesis
- asthenozoospermia
- bradykinesia
- decreased aggression
- decreased aggression towards males
- decreased bone mass
- decreased bone mineral density
- decreased circulating estradiol level
- decreased heart rate variability
- decreased male germ cell number
- decreased mean systemic arterial blood pressure
- decreased systemic arterial diastolic blood pressure
- decreased testis weight
- decreased uterus weight
- enlarged clitoris
- enlarged liver
- enlarged mesenteric lymph nodes
- enlarged prostate gland
- enlarged salivary gland
- enlarged spleen
- failure of ejaculation
- female infertility
- hepatic steatosis
- impaired glucose tolerance
- impaired luteinization
- impaired ovarian folliculogenesis
- increased B cell number
- increased IgG level
- increased abdominal adipose tissue amount
- increased abdominal fat pad weight
- increased aggression towards females
- increased anti-single stranded DNA antibody level
- increased autoantibody level
- increased body weight
- increased bone marrow cell number
- increased bone resorption
- increased cardiac muscle contractility
- increased circulating HDL cholesterol level
- increased circulating dihydrotestosterone level
- increased circulating follicle stimulating hormone level
- increased circulating glucose level
- increased circulating insulin level
- increased circulating leptin level
- increased circulating luteinizing hormone level
- increased circulating prolactin level
- increased circulating testosterone level
- increased circulating triglyceride level
- increased dendritic cell number
- increased fat cell size
- increased gonadal fat pad weight
- increased granulocyte number
- increased granulosa cell apoptosis
- increased grooming behavior
- increased heart rate
- increased leukocyte cell number
- increased lymphocyte cell number
- increased macrophage cell number
- increased mammary fat pad weight
- increased mature B cell number
- increased osteoclast cell number
- increased ovary apoptosis
- increased prostate gland weight
- increased renal fat pad weight
- increased seminal vesicle weight
- increased susceptibility to autoimmune disorder
- increased susceptibility to weight gain
- increased urine protein level
- insulin resistance
- kidney inflammation
- lacrimal gland inflammation
- male infertility
- no abnormal phenotype detected
- obese
- oligozoospermia
- ovary cysts
- ovary hemorrhage
- pale liver
- prostate gland hyperplasia
- reduced male fertility
- reduced male mating frequency
- renal glomerular immunoglobulin deposits
- salivary gland inflammation
- small uterus
- spleen hyperplasia
- thin endometrium
- thin myometrium
- uterus hypoplasia
role in cell
- apoptosis
- inhibition in
- number
- proliferation
- invasion by
- quantity
- expression in
- influx
- chemotaxis
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- intracellular compartment
- presynaptic regions
- Golgi region
- intracellular space
- basal compartment
- perinuclear region
- postsynaptic region
- cellular membrane
- Endoplasmic Reticulum
- flagella
- endoplasmic reticulum membrane
- residual bodies
- dendritic spines
- synaptic vesicles
- rough endoplasmatic reticulum
- perikaryon
- dendrites
- postsynaptic density
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cyp19a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- uterus development
- prostate gland growth
- steroid biosynthetic process
- female gonad development
- androgen catabolic process
- estrogen biosynthetic process
- negative regulation of chronic inflammatory response
- mammary gland development
- positive regulation of estradiol secretion
- syncytium formation
- response to estradiol stimulus
- testosterone biosynthetic process
- female genitalia development
- negative regulation of macrophage chemotaxis
- sterol metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- oxygen binding
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
- iron ion binding
- steroid hydroxylase activity
- electron carrier activity
- aromatase activity
- heme binding