Il1rn Gene Summary [Rat]
Enables interleukin-1 receptor binding activity. Involved in several processes, including cellular response to norepinephrine stimulus; chronic inflammatory response to antigenic stimulus; and fever generation. Located in extracellular space. Used to study adult respiratory distress syndrome; anti-basement membrane glomerulonephritis; hypertension; silicosis; and transient cerebral ischemia. Biomarker of encephalitis and pneumonia. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); kidney failure (multiple); lung disease (multiple); and vascular disease (multiple). Orthologous to human IL1RN (interleukin 1 receptor antagonist). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il1rn |
| Official Name | interleukin 1 receptor antagonist [Source:RGD Symbol;Acc:621159] |
| Ensembl ID | ENSRNOG00000005871 |
| Bio databases IDs | |
| Aliases | interleukin 1 receptor antagonist |
| Synonyms | CRMO2, DIRA, F630041P17Rik, IL1F3, IL-1RA, IL-1 receptor ANTAGONIST, interleukin 1 receptor antagonist, IRA, IRAP, MVCD4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il1rn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-1 Type I receptor antagonist
- interleukin-1 receptor antagonist
- interleukin-1 receptor binding
- cell penetrating signal sequence
- interleukin-1, Type II receptor binding
- protein binding
- cytokine
- beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines
- interleukin-1 Type II receptor antagonist
- interleukin-1, Type I receptor binding
Pathways
Biological processes and signaling networks where the Il1rn gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Adrenomedullin signaling pathway
- Agranulocyte Adhesion and Diapedesis
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Atherosclerosis Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- Communication between Innate and Adaptive Immune Cells
- Dendritic Cell Maturation
- FXR/RXR Activation
- Glucocorticoid Receptor Signaling
- Graft-versus-Host Disease Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Cholestasis
- IL-10 Signaling
- IL-6 Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- NF-κB Signaling
- p38 MAPK Signaling
- PPAR Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fibrosis
- cancer
- neoplasia
- metastasis
- experimental autoimmune encephalomyelitis
- renal cell cancer
- COVID-19
- non-insulin-dependent diabetes mellitus
- systemic lupus erythematosus
- chronic periodontal disease
phenotypes
- Abscess
- Acute Liver Failure
- Acute Lung Injury
- Acute Necrotizing Pancreatitis
- Anorexia
- B-Cell Chronic Lymphocytic Leukemia
- Behcet's disease
- Bronchial Hyperreactivity
- Bronchopulmonary Dysplasia
- Cachexia
- Calcium Oxalate Nephrolithiasis
- Carotid Artery Injuries
- Cerebral Hemorrhage
- Chronic Rhinosinusitis
- Chronic Uveitis
- Corneal Graft Rejection
- Cryopyrin-Associated Periodic Syndromes
- Diabetes Mellitus Experimental
- Diabetic Nephropathies
- Drug Hypersensitivity Syndrome
- Drug-induced agranulocytosis
- Endotoxemia
- Endotoxin-Induced Uveitis
- Experimental Arthritis
- Experimental Autoimmune Encephalomyelitis
- experimental autoimmune myocarditis
- Experimental Autoimmune Uveitis
- Experimental Colitis
- Eye Manifestations
- Febrile Seizures
- Graft vs Host Disease
- Graves Ophthalmopathy
- Henoch-Schoenlein purpura
- human influenza
- Hyperalgesia
- IgA glomerulonephritis
- Inflammation
- Kidney Reperfusion Injury
- Leukocytosis
- Lichen Sclerosus et Atrophicus
- Liver Reperfusion Injury
- Mammary Neoplasms Experimental
- Meibomian Gland Dysfunction
- Muckle-Wells Syndrome
- Multiple Organ Failure
- Myocardial Reperfusion Injury
- Oligoanuria
- Postoperative Cognitive Dysfunction
- Proctocolitis
- Pseudomonas Aeruginosa Keratitis
- Pseudomonas Infections
- Schnitzler Syndrome
- Sepsis
- Serositis
- Sjogren's Syndrome
- Spinal Cord Injuries
- Stroke
- Subarachnoid Hemorrhage
- Tobacco Use Disorder
- Transplant Rejection
- Urinary Calculi
- Uveitis Chronic Anterior
- Venous Thrombosis
- Ventilator-Induced Lung Injury
- viral bronchiolitis
- acute kidney failure
- adult respiratory distress syndrome
- allergic conjunctivitis
- Alopecia Areata
- anterior uveitis
- anti-basement membrane glomerulonephritis
- asthma
- autoimmune thrombocytopenic purpura
- autosomal dominant polycystic kidney disease
- bacterial pneumonia
- Bronchiolitis
- Bronchiolitis Obliterans
- bronchus carcinoma
- chronic kidney disease
- chronic myeloid leukemia
- chronic obstructive pulmonary disease
- cicatricial pemphigoid
- Common Cold
- Corneal Neovascularization
- crescentic glomerulonephritis
- Cystic Fibrosis
- Dacryocystitis
- dry eye syndrome
- encephalitis
- end stage renal failure
- Fibromyalgia
- Glomerulonephritis
- hairy cell leukemia
- Hemolytic-Uremic Syndrome
- herpes simplex virus keratitis
- Hyperglycemia
- hypertension
- inflammatory bowel disease
- interstitial lung disease
- Keratoconus
- learning disability
- Listeriosis
- Lupus Nephritis
- melanoma
- mental depression
- middle cerebral artery infarction
- morbid obesity
- Multiple Myeloma
- Myositis
- Nephrotic Syndrome
- non-small cell lung carcinoma
- obesity
- Osteoporosis
- Periodontitis
- pleural disease
- pleural tuberculosis
- Pleurisy
- Pneumonia
- Pre-Eclampsia
- Prostatitis
- Proteinuria
- Pulmonary Eosinophilia
- Pulmonary Fibrosis
- pulmonary hypertension
- pulmonary sarcoidosis
- pulmonary tuberculosis
- Pyelonephritis
- renal cell carcinoma
- respiratory allergy
- rheumatoid arthritis
- Rhinitis
- Sciatic Neuropathy
- Silicosis
- systemic lupus erythematosus
- toxic shock syndrome
- transient cerebral ischemia
- type 1 diabetes mellitus
- type 2 diabetes mellitus
- ulcerative colitis
- Ureteral Obstruction
- urinary bladder cancer
- vascular disease
- lung non-small cell carcinoma
- Non-alcoholic Fatty Liver Disease
- end stage renal disease
- Experimental Diabetes Mellitus
role in cell
- migration
- proliferation
- necrosis
- expression in
- phosphorylation in
- growth
- cell death
- differentiation
- production in
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- Cytoplasm
- cell surface
- intracellular space
- Plasma Membrane
- endosomes
- vesicles
- centrosome
- cytosol
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il1rn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- insulin secretion
- inflammatory response to antigenic stimulus
- signal transduction
- response to glucocorticoid stimulus
- lipid metabolic process
- negative regulation of heterotypic cell-cell adhesion
- negative regulation of interleukin-1-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- centrosome
- extracellular vesicular exosome
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- interleukin-1 Type II receptor antagonist activity
- interleukin-1, Type I receptor binding
- interleukin-1 receptor antagonist activity
- interleukin-1, Type II receptor binding
- interleukin-1 Type I receptor antagonist activity
- cytokine activity