Havcr1 Gene Summary [Rat]
Predicted to enable phosphatidylserine binding activity and virus receptor activity. Involved in several processes, including phagocytosis, engulfment; response to mycotoxin; and response to testosterone. Located in several cellular components, including apical plasma membrane; cell surface; and phagocytic vesicle. Biomarker of colitis; hypertension; kidney failure (multiple); and proteinuria (multiple). Human ortholog(s) of this gene implicated in atopic dermatitis. Orthologous to human HAVCR1 (hepatitis A virus cellular receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Havcr1 |
| Official Name | hepatitis A virus cellular receptor 1 [Source:RGD Symbol;Acc:708425] |
| Ensembl ID | ENSRNOG00000007243 |
| Bio databases IDs | |
| Aliases | hepatitis A virus cellular receptor 1 |
| Synonyms | hepatitis A virus cellular receptor 1, Kidney Injury Molecule1, KIM-1, Tim-1 |
| Species | Rat, Rattus norvegicus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Havcr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- binding protein
- viral receptor
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- proteinuria
- streptozotocin-induced diabetic nephropathy
- proximal tubular toxicity
- nephrotoxicity
- experimental autoimmune encephalomyelitis
- polycystic kidney disease
- renal ischemia
phenotypes
- Albuminuria
- Cardio-Renal Syndrome
- Contrast-Induced Nephropathy
- Diabetic Nephropathies
- Hyperoxaluria
- IgA glomerulonephritis
- Kidney Reperfusion Injury
- Rhabdomyolysis
- Sepsis
- Transplant Rejection
- acute kidney failure
- acute kidney tubular necrosis
- asthma
- atopic dermatitis
- autosomal dominant polycystic kidney disease
- chronic kidney disease
- colitis
- essential hypertension
- Hydronephrosis
- hypertension
- Hyperuricemia
- kidney disease
- Nephrosis
- Proteinuria
- relapsing-remitting multiple sclerosis
- renal cell carcinoma
- Renal Fibrosis
- renovascular hypertension
- Ureteral Obstruction
- vesicoureteral reflux
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- motile cilia
- cell surface
- Extracellular Space
- membrane surface
- cellular membrane
- apical cell surfaces
- apical membrane
- brush border
- phagosomes