TUBG1 Gene Summary [Human]

This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7. [provided by RefSeq, Jan 2009]

Details

Type
Retained Intron
Official Symbol
TUBG1
Official Name
tubulin gamma 1 [Source:HGNC Symbol;Acc:HGNC:12417]
Ensembl ID
ENSG00000131462
Bio databases IDs NCBI: 7283 Ensembl: ENSG00000131462
Aliases tubulin gamma 1
Synonyms 1500010O08RIK, CDCBM4, Gamma-1 tubulin, Gamma-tubulin, GCP-1, TUBG, TUBGCP1, tubulin gamma 1, tubulin, gamma 1, tubulin γ 1, tubulin, γ 1, γ-1 tubulin, γ-tubulin
Species
Human, Homo sapiens
OrthologiesMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TUBG1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Tubulin protein family of FtsZ and CetZ-like
  • Tubulin C-terminal domain
  • structural constituent of cytoskeleton
  • Tubulin/FtsZ family, GTPase domain
  • protein binding
  • Tubulin/FtsZ family, C-terminal domain
  • identical protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • skin cancer
  • cancer
  • prostate cancer
  • breast cancer
  • lung cancer
  • asthma
  • pain
  • bleeding
  • cervical cancer
  • pancreatic neoplasm
regulated by
role in cell
  • expression in
  • proliferation
  • apoptosis
  • migration
  • invasion by
  • regrowth
  • organization
  • downregulation in
  • upregulation in
  • abnormal morphology

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • nuclear fraction
  • pericentriolar matrix
  • centriolar satellite
  • non-motile cilium
  • cilia
  • apical compartment
  • pericentriolar regions
  • Nucleus
  • basal bodies
  • centrosome
  • centriole
  • microtubule organizing centers
  • cytosol
  • chromosome
  • nucleoli
  • spindle pole
  • spindle fibers
  • nuclear envelope
  • neurites
  • recycling endosomes
  • cytoplasmic microtubule
  • polar microtubule
  • cell membrane leading edge
  • centromeres
  • chromatin
  • dendritic knobs
  • centrosomal fraction
  • cytosolic fraction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human TUBG1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • mitotic spindle organization
  • microtubule nucleation
  • mitotic sister chromatid segregation
  • microtubule cytoskeleton organization
  • cytoplasmic microtubule organization
  • mitotic cell cycle
  • meiotic spindle organization

Cellular Component

Where in the cell the gene product is active
  • cell leading edge
  • cilium basal body
  • gamma-tubulin complex
  • cytoplasmic microtubule
  • neuron projection
  • condensed nuclear chromosome
  • microtubule
  • pericentriolar material
  • nucleus
  • centrosome
  • apical part of cell
  • cytoplasm
  • centriole
  • polar microtubule
  • spindle
  • cytosol
  • recycling endosome

Molecular Function

What the gene product does at the molecular level
  • GTP binding
  • identical protein binding
  • protein binding
  • structural constituent of cytoskeleton

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.