KLRB1 Gene Summary
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | KLRB1 |
| Official Name | killer cell lectin like receptor B1 [Source:HGNC Symbol;Acc:HGNC:6373] |
| Ensembl ID | ENSG00000111796 |
| Bio databases IDs | |
| Aliases | killer cell lectin like receptor B1, natural killer cell surface protein P1A |
| Synonyms | 4930431A04Rik,CD161,CLEC5B,Gm4696,hNKR-P1A,killer cell lectin like receptor B1,killer cell lectin-like receptor subfamily B member 1,Klrb1d,Klrb1f,Klrb1g,Klrb6,LOC100048690,LOC683766,Ly-55,NKR,NKR-P1,NKR-P1A,Nkr-p1e,NKR-P1G |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- cytoplasmic domain
- ectodomain
- Lectin C-type domain
- protein binding
- carbohydrate binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the KLRB1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- epithelial cancer
- urothelial bladder carcinoma
- systemic lupus erythematosus
- acute myeloid leukemia
- hepatocellular carcinoma
- sarcoidosis
- sepsis
- organismal death
- renal clear cell adenocarcinoma
role in cell
- apoptosis
- production in
- signaling in
- proliferation
- invasion by
- migration
- S phase progression
- secretion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the KLRB1 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- cell surface receptor signaling pathway
- regulation of natural killer cell mediated cytotoxicity
cellular COMPONENT
Where in the cell the gene product is active
- plasma membrane
- cell surface
molecular FUNCTION
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- protein binding
- signaling receptor activity
- carbohydrate binding