WNT2B Gene Summary
This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Details
| Type | Protein Coding |
| Official Symbol | WNT2B |
| Official Name | Wnt family member 2B [Source:HGNC Symbol;Acc:HGNC:12781] |
| Ensembl ID | ENSG00000134245 |
| Bio databases IDs | |
| Aliases | Wnt family member 2B, XWNT2, Xenopus, homolog of, wingless-type MMTV integration site family, member 13 |
| Synonyms | wingless-type MMTV integration site family, member 2B,WNT13,Wnt2a,Wnt family member 2B |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt
- wnt family
- protein binding
- receptor binding
- found in Wnt-1
Pathways
Biological processes and signaling networks where the WNT2B gene plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Ovarian Cancer Signaling
- PCP pathway
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Transcriptional Regulatory Network in Embryonic Stem Cells
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- hypertension
- primary biliary cirrhosis
- stroke
- squamous cell lung cancer
- diarrhea type 9
- lung adenocarcinoma
- lung adenocarcinoma formation
- cardiovascular disorder
- androgenic alopecia
role in cell
- proliferation
- phosphorylation in
- expression in
- binding in
- formation
- production in
- activation in
- oxidation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the WNT2B gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- male gonad development
- neuron differentiation
- lung induction
- chondrocyte differentiation
- cellular response to starvation
- mesenchymal-epithelial cell signaling
- lens development in camera-type eye
- cornea development in camera-type eye
- forebrain regionalization
- positive regulation of branching involved in ureteric bud morphogenesis
- cell fate commitment
- hemopoietic stem cell proliferation
- canonical Wnt receptor signaling pathway
- iris morphogenesis
cellular COMPONENT
Where in the cell the gene product is active
- extracellular space
- intracellular membrane-bounded organelle
- extracellular region
molecular FUNCTION
What the gene product does at the molecular level
- frizzled binding
- cytokine activity