Casp4 Gene Summary [Rat]
Enables scaffold protein binding activity. Predicted to be involved in several processes, including cellular response to amyloid-beta; positive regulation of signal transduction; and response to bacterium. Predicted to act upstream of or within ectopic germ cell programmed cell death; positive regulation of cytokine production; and pyroptotic inflammatory response. Located in neuronal cell body. Part of protein-containing complex. Orthologous to several human genes including CASP4 (caspase 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Casp4 |
| Official Name | caspase 4 [Source:RGD Symbol;Acc:621757] |
| Ensembl ID | ENSRNOG00000033697 |
| Bio databases IDs | |
| Aliases | caspase 4 |
| Synonyms | CASP-11, Casp13, Caspase 11, Caspase 13, caspase 4, caspase 4, apoptosis-related cysteine peptidase, Caspl, ich-3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Casp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CARD domain binding
- CASc
- Caspase recruitment domain
- cysteine endopeptidase
- lipid binding
- peptidase
- protein binding
- lipopolysaccharide binding
- Death Domain Superfamily of protein-protein interaction domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- gastritis
- flu
- endotoxin shock response
- experimental autoimmune encephalomyelitis
- gait disturbance
- septic cardiomyopathy
- shock response
- tumorigenesis
- cerebral hemorrhage
role in cell
- activation in
- formation
- formation in
- apoptosis
- replication in
- cell death
- number
- loss
- phosphorylation in
- proteolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- membrane processes
- perikaryon