Basal Cell Carcinoma Signaling
Basal cell carcinoma (BCC) is the most common form of skin cancer. The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog signaling.Ligand-dependent signaling by Hedgehog (Hh) homologs proceeds through association with the Patched receptor. This association relieves the Patched-mediated inhibition of the SMO receptor. Signaling via the SMO receptor releases the transcription factor Gli from an inhibitory cytoplasmic multiprotein complex...
Pathway Summary
Basal cell carcinoma (BCC) is the most common form of skin cancer. The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog signaling.Ligand-dependent signaling by Hedgehog (Hh) homologs proceeds through association with the Patched receptor. This association relieves the Patched-mediated inhibition of the SMO receptor. Signaling via the SMO receptor releases the transcription factor Gli from an inhibitory cytoplasmic multiprotein complex. Subsequent nuclear translocation of Gli results in the expression of genes like BMP, Wnt, PTCH and Gli1 itself, resulting in cell proliferation. The mutations in SMO, PTCH1, and SHH in BCCs result in constitutive activation of target genes. Mutations in TP53, which occur at a high frequency in sporadic BCC, result in genomic instability and cell survival.
Basal Cell Carcinoma Signaling Genes list
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APCAPC regulator of WNT signaling pathway APC2APC regulator of WNT signaling pathway 2 AXIN1axin 1 BMP1bone morphogenetic protein 1 BMP10bone morphogenetic protein 10 BMP15bone morphogenetic protein 15 BMP2bone morphogenetic protein 2 BMP3bone morphogenetic protein 3 BMP4bone morphogenetic protein 4 BMP5bone morphogenetic protein 5 BMP6bone morphogenetic protein 6 BMP7bone morphogenetic protein 7 BMP8Abone morphogenetic protein 8a BMP8Bbone morphogenetic protein 8b CTNNB1catenin beta 1 FZD1frizzled class receptor 1 FZD10frizzled class receptor 10 FZD2frizzled class receptor 2 FZD3frizzled class receptor 3 FZD4frizzled class receptor 4 FZD5frizzled class receptor 5 FZD6frizzled class receptor 6 FZD7frizzled class receptor 7 FZD8frizzled class receptor 8 FZD9frizzled class receptor 9 GLI1GLI family zinc finger 1 GLI2GLI family zinc finger 2 GLI3GLI family zinc finger 3 GLIS1GLIS family zinc finger 1 GLIS2GLIS family zinc finger 2 GSK3Bglycogen synthase kinase 3 beta HHIPhedgehog interacting protein HNF1AHNF1 homeobox A KIF7kinesin family member 7 LEF1lymphoid enhancer binding factor 1 PTCH1patched 1 PTCH2patched 2 SHHsonic hedgehog signaling molecule SMOsmoothened, frizzled class receptor STK36serine/threonine kinase 36 SUFUSUFU negative regulator of hedgehog signaling TCF3transcription factor 3 TCF4transcription factor 4 TCF7transcription factor 7 TCF7L1transcription factor 7 like 1 TCF7L2transcription factor 7 like 2 TP53tumor protein p53 WNT1Wnt family member 1 WNT10AWnt family member 10A WNT10BWnt family member 10B WNT11Wnt family member 11 WNT16Wnt family member 16 WNT2Wnt family member 2 WNT2BWnt family member 2B WNT3Wnt family member 3 WNT3AWnt family member 3A WNT4Wnt family member 4 WNT5AWnt family member 5A WNT5BWnt family member 5B WNT6Wnt family member 6 WNT7AWnt family member 7A WNT7BWnt family member 7B WNT8AWnt family member 8A WNT8BWnt family member 8B WNT9AWnt family member 9A WNT9BWnt family member 9B ZNF875zinc finger protein 875
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