Target List
Bladder Cancers
Adenocarcinomas
KRAS, TP53 (p53)
Transitional Cell Carcinomas
AKT1, ARID1A, ATM, BRAF, CCND1, CCNE1, CDKN2A (P16INK4A), CTNNB1, ERBB2 (HER-2, NEU), ERBB3, ERCC2 (XPD), FGFR2, FGFR3, HRAS, KDM6A, KRAS, PIK3CA (p110-alpha), PTEN, RB1, TP53 (p53)
Brain Cancers
Anaplastic Glial Tumors
PTEN, TP53 (p53)
Astrocytomas
BRAF, CHEK2 (RAD53), FGFR1, IDH1, KRAS, PTPN11, TP53 (p53)
Ependymomas
H3-3A, NF2
Glioblastomas
APC, BCOR, BRAF, CREBBP (CBP), EGFR (ERBB1), H3-3A, IDH1, MLH1, MSH2, MTOR, NRAS, PIK3CA (p110-alpha), PMS2, PMS2CL, PTEN, TERT, TP53 (p53)
Gliomas
ACVR1 (ALK2), BRCA2, CHEK2 (RAD53), FGFR1, H3-3A, PIK3CA (p110-alpha), PTEN, TP53 (p53)
High-Grade Gliomas
BRAF, EGFR (ERBB1), IDH1
Medulloblastomas
BRCA2, CREBBP (CBP), FGFR1, IDH1, MSH2, NRAS, PIK3CA (p110-alpha), PTCH2, SUFU, TP53 (p53)
Meningiomas
NF2, PTEN
Oligodendrogliomas
IDH1, MSH2, TERT
Breast Cancers
Carcinomas
ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1 (E-Cadherin), CDK12, CDK4, CHEK1, CHEK2 (RAD53), EGFR (ERBB1), ERBB2 (HER-2, NEU), ESR1 (ERα), FANCL, FBXW7, KIT (CD117), KRAS, MET, MLH1, MLH3, MSH2, MSH3, MSH6, PALB2, PDGFRA, PIK3CA (p110-alpha), PMS1, PMS2, RAD51B, RAD51C, RAD51D, RAD54L, SF3B1
Metastatic Breast Cancers
AKT1, BRCA1, BRCA2, ERBB2 (HER-2, NEU), ERBB3, ESR1 (ERα), PALB2, PIK3CA (p110-alpha), PTEN
Mismatch Repair (MMR) Genes
MLH1, MSH2, MSH6, PMS2
Colorectal Cancers
Adenocarcinomas
APC, ARID1A, ATM, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CDK12, CDKN2A (P16INK4A), CHEK1, CHEK2 (RAD53), CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), ERBB3, FANCL, FBXW7, GNAS, KIT (CD117), KRAS, MAP2K1, MET, MLH1, MLH3, MSH2, MSH3, MSH6, MYC, NRAS, PALB2, PDGFRA, PMS1, PMS2, PMS2CL, POLE, PTEN, RAD51B, RAD51C, RAD51D, RAD54L, RET, RNF43, SMAD4 (MADH4), TCF7L2, TGFBR2, TP53 (p53)
Metastatic Colorectal Cancers
AKT1, ATM, BRAF, ERBB2 (HER-2, NEU), KRAS, MET, NRAS, PIK3CA (p110-alpha)
Mismatch Repair (MMR) Genes
MLH1, MSH2, MSH6, PMS2, PMS2CL
Other Colorectal Cancer Genes
DPYD, ERCC1, TYMS, UGT1A1
Gastric Cancers
Adenocarcinomas
APC, ARID1A, CDKN2A (P16INK4A), CTNNB1, ERBB2 (HER-2, NEU), ERBB3, FBXW7, GNAS, KMT2D, KRAS, MYC, PIK3CA (p110-alpha), PTEN, RNF43, SMAD4 (MADH4), TP53 (p53)
Adenomas
APC, CTNNB1, GNAS, KRAS
Gastrointestinal Stromal Tumors (GIST)
BRAF, KIT (CD117), PDGFRA
Other Gastric Cancer Genes
CDH1 (E-Cadherin), MET
Liver Cancers
Advanced Cholangiocarcinomas
BRAF, IDH1
Hepatoblastomas
CTNNB1, TP53 (p53)
Hepatocellular Carcinomas
ALB, APC, APOB, ARID1A, ARID2, AXIN1, CCND1, CDKN2A (P16INK4A), CREBBP (CBP), CTNNB1, IDH1, IDH2, JAK1, KEAP1, KRAS, MYC, NFE2L2, NRAS, PIK3CA (p110-alpha), RB1, RIT1, TERT, TP53 (p53), TSC2
Lung Cancers
Adenocarcinomas
ABL1, ALK, ATM, BRAF, CDK4, CDKN2A (P16INK4A), CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), KRAS, MAP2K1, MET, NRAS, NTRK1, PIK3CA (p110-alpha), PTEN, RET, ROS1, TP53 (p53), TSC2
Malignant Pleural Mesotheliomas
NF2
Non-Small Cell Lung Cancers (NSCLC)
ALK, ATM, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CDK12, CDK4, CDKN2A (P16INK4A), CHEK1, CHEK2 (RAD53), CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), FANCL, KIT (CD117), KRAS, MAP2K1, MET, MLH1, MLH3, MSH2, MSH3, MSH6, NRAS, PALB2, PDGFRA, PIK3CA (p110-alpha), PMS1, PMS2, PTEN, RAD51B, RAD51C, RAD51D, RAD54L, RET, ROS1, TP53 (p53)
Small Cell Lung Cancers (SCLC)
NTRK1, PIK3CA (p110-alpha), PTEN, RB1, TP53 (p53)
Squamous Cell Carcinomas
BRAF, CDKN2A (P16INK4A), EGFR (ERBB1), NTRK1, PIK3CA (p110-alpha), PTEN, TP53 (p53), TSC2
Melanomas
Cutaneous Melanomas
KRAS, MLH1, MLH3, MSH2, MSH6, NRAS
Malignant Melanomas
AKT3, ARID2, BRAF, CCND1, CDK4, CDKN2A (P16INK4A), CREBBP (CBP), CTNNB1, ERBB4, EZH2, GNA11, GNAQ, GRIN2A, HRAS, IDH1, KIT (CD117), KRAS, MAP2K1, MAP2K2 (MEK2), MITF, NF1, NRAS, PIK3CA (p110-alpha), PPP6C, PTEN, RAC1, RAF1, RB1, TERT, TP53 (p53)
Mucosal Melanomas
BRAF, KIT (CD117), MLH1, MLH3, MSH2, MSH6, NRAS
Ocular Melanomas
MLH1, MLH3, MSH2, MSH6
Uveal Melanomas
ATM, BAP1, BRCA1, BRCA2, CDK12, EGFR (ERBB1), FANCL, KRAS, MLH1, MLH3, MSH2, MSH6, NRAS, PALB2, PLCB4
Other Melanoma Genes
BARD1, BRIP1, CHEK1, CHEK2 (RAD53), PDGFRA, RAD51B, RAD51C, RAD51D
Myeloid Neoplasms
Acute Lymphoblastic Leukemia (ALL)
ABL1, BRAF, BTK, CDKN2A (P16INK4A), CREBBP (CBP), ETV6, FBXW7, FLT3, HRAS, JAK1, JAK2, JAK3, KMT2A, KRAS, MYC, NOTCH1, NRAS, PTEN, PTPN11, RUNX1 (AML1), SF3B1, TP53 (p53)
Acute Myeloid Leukemia (AML)
ASXL1, ATRX, BRCA1, BRCA2, CBLB, CBLC, CEBPA, DNMT3A, ETV6, FLT3, GATA1, GATA2, GNAS, HRAS, IDH1, IDH2, JAK2, KIT (CD117), KMT2A, KRAS, MTOR, NPM1, NRAS, PDGFRA, PTPN11, RUNX1 (AML1), SF3B1, SMC1A, TET2, TP53 (p53), U2AF1, WT1
Acute Promyelocytic Leukemia (APML; APL)
CEBPA, NPM1, RUNX1 (AML1)
Atypical Chronic Myeloid Leukemia (aCML)
ASXL1, CBL, CEBPA, EZH2, FLT3, JAK2, KRAS, NPM1, NRAS, RUNX1 (AML1), SETBP1, SRSF2, TET2, U2AF1
Chronic Lymphocytic Leukemia (CLL)
ATRX, BCL2, BRAF, CBLB, GNAS, GNB1, MYD88, NOTCH1, NRAS, PTPN11, SF3B1, TP53 (p53), XPO1
Chronic Myeloid Leukemia (CML)
ABL1, ASXL1, BCOR, BRAF, CBL, CREBBP (CBP), DNMT3A, EZH2, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1 (AML1), TET2, TP53 (p53), WT1
Chronic Myelomonocytic Leukemia (CMML)
ASXL1, BCOR, BCORL1, CBL, CEBPA, DNMT3A, EZH2, FLT3, IDH1, IDH2, JAK2, KIT (CD117), KRAS, MPL, NF1, NPM1, NRAS, PHF6, PTPN11, RUNX1 (AML1), SETBP1, SF3B1, SRSF2, STAG2, TET2, TP53 (p53), U2AF1, ZRSR2
Hairy Cell Leukemia
BRAF, TP53 (p53)
Juvenile Myelomonocytic Leukemia
CBL, KRAS, NRAS, PTPN11
Acute Lymphocytic Lymphomas
BTK, CDKN2A (P16INK4A), MYC, NOTCH1, SF3B1, TP53 (p53)
B Cell Lymphomas
BCL6, BRAF, CHEK2 (RAD53), EZH2, MYD88, TP53 (p53)
Burkitt Lymphomas
CBLB, GNA13, MTOR, MYC
Diffuse Large B Cell Lymphomas
B2M, BCL2, CBLB, GNA13, KMT2D, MTOR, PIM1, SOCS1, TNFAIP3
Follicular Lymphomas
ARID1A, BCL2, CARD11, CREBBP (CBP), EZH2, KMT2D
Mantle Cell Lymphomas
ATM
Marginal Zone Lymphomas
MYD88, TNFAIP3, TP53 (p53)
Mucosa-Associated Lymphoid Tissue (MALT) Lymphomas
TNFAIP3
Non-Hodgkin Lymphomas
BRAF, NRAS, PIK3CA (p110-alpha), TP53 (p53)
Primary Cutaneous Lymphomas
CD79B, MYD88
Small Lymphocytic Lymphomas
ATRX, BCL2, CBLB, GNAS, XPO1
T Cell Lymphomas
ATM, CBLB, DNMT3A, IDH1, IDH2, JAK1, JAK3, RHOA, STAT3, STAT5B, TET2
Myelodysplastic Syndromes
ASXL1, ATRX, BCOR, BCORL1, CALR, CBL, CEBPA, CSF3R (GM-CSFR), DNMT3A, ETV6, EZH2, FLT3, GATA2, GNAS, GNB1, IDH1, IDH2, JAK2, JAK3, KIT (CD117), KRAS, MPL, NF1, NPM1, NRAS, PHF6, PPM1D, PTPN11, RAD21, RUNX1 (AML1), SETBP1, SF3B1, SMC3, SRSF2, STAG2, STAT3, TET2, TP53 (p53), U2AF1, WT1, ZRSR2
Myeloproliferative Neoplasms
ASXL1, CALR, CBL, DNMT3A, EZH2, IDH1, IDH2, JAK2, MPL, RUNX1 (AML1), SF3B1, SRSF2, TP53 (p53), U2AF1
Essential Thrombocythemia
ASXL1, CBL, IDH2, JAK2, MPL, SF3B1, TET2, TP53 (p53)
Multiple Myeloma
ATM, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CHEK1, CHEK2 (RAD53), EGFR (ERBB1), ERBB2 (HER-2, NEU), FANCL, FGFR3, IDH1, IDH2, KIT (CD117), KRAS, MET, NRAS, PALB2, PDGFRA, RAD51B, RAD51C, RAD51D, RET, TP53 (p53)
Plasma Cell Myeloma
HRAS, MTOR
Polycythemia Vera
ASXL1, DNMT3A, EZH2, IDH1, JAK2, NRAS, TET2, TP53 (p53)
Primary Myelofibrosis
ASXL1, CBL, DNMT3A, EZH2, IDH1, IDH2, JAK2, MPL, NF1, NRAS, SETBP1, SF3B1, SRSF2, TET2, TP53 (p53)
Systemic Mastocytosis
ASXL1, CBL, DNMT3A, ETV6, EZH2, IDH2, JAK2, KIT (CD117), KRAS, NPM1, NRAS, RUNX1 (AML1), SETBP1, SF3B1, SRSF2, TET2, U2AF1
Waldenstrom Macroglobulinemia
MYD88
Ovarian Cancers
Endometrioid Carcinomas
CTNNB1, POLE, PPP2R1A
Epithelial Carcinomas
ARID1A, BRCA1, BRCA2, CCNE1, CHEK2 (RAD53), ERBB2 (HER-2, NEU), KRAS, PIK3CA (p110-alpha), PTEN, RB1, TP53 (p53)
Granulosa Cell Tumors
AKT1, FOXL2
Mixed Adenosquamous Carcinomas
AKT1, CCNE1, ERBB3, FANCM, FBXW7, FGFR2, MYC, PIK3R1 (p85-ALPHA), POLE, RB1, STK11 (LKB1)
Mucinous Carcinomas
ERBB3
Serous Carcinomas
CCNE1, ERBB3, FANCM, FBXW7, FGFR2, MYC, PPP2R1A, RB1
Pancreatic Cancers
Adenocarcinomas
CDKN2A (P16INK4A), MSH6, PMS2, SMAD4 (MADH4), TP53 (p53)
Advanced Ductal Adenocarcinomas
BRAF, BRCA1, BRCA2, ERBB2 (HER-2, NEU), KRAS, PIK3CA (p110-alpha)
Ductal Carcinomas
APC, ARID1A, CTNNB1, ERBB3, FBXW7, GNAS, MYC, NRAS, POLE, PTEN, RNF43, TCF7L2
Mismatch Repair (MMR) Genes
MSH6, PMS2
Prostate Cancers
Adenocarcinomas
APC, AR, BRAF, CHEK2 (RAD53), FOXA1, HRAS, IDH1, KDM6A, KMT2D, KRAS, MED12, MYC, PIK3R1 (p85-ALPHA), PTEN, RB1, SPOP, TP53 (p53)
Advanced Prostate Cancers
AKT1, BRCA2, PIK3CA (p110-alpha), PTEN
Ductal Carcinomas
CTNNB1