Target List
ATM / ATR Signaling
ATM, ATR, ATRIP, BARD1, BRCA1, CDC25A, CHEK1, CHEK2 (RAD53), CSNK2A2, FANCD2, H2AFX, HUS1, MDC1, PARP1 (ADPRT1), RAD1, RAD17, RAD50, RAD9A, RBBP8, RNF168, RNF8, SMC1A, TOPBP1, TP53 (p53)
DNA Damage & Repair
Nucleotide Excision Repair (NER)
CDK7, DDB1, DDB2, ERCC1, ERCC2 (XPD), LIG1, NTHL1, OGG1, PCNA, PNKP, RPA1, SIRT1, TP53 (p53), XPA, XPC
Base Excision Repair (BER)
APEX1, FEN1, LIG1, MBD4, MPG, NTHL1, OGG1, PARP1 (ADPRT1), PCNA, TP53 (p53), UNG, XRCC1
Mismatch Repair (MMR)
ABL1, EXO1, MLH1, MLH3, MSH2, MSH3, PCNA, PMS1, PMS2, TP73
Double-Strand Break (DSB) Repair
ATM, BLM, BRCA1, CHEK1, H2AFX, HUS1, LIG1, MDC1, MLH1, MRE11, NBN, PRKDC, RAD50, RAD51, RPA1, TP53BP1, XRCC2, XRCC6
Other DNA Repair Genes
ATR, ATRIP, ATRX, BARD1, BRIP1, CHEK2 (RAD53), CIB1, CRY1, FANCA, FANCD2, FANCG, GADD45A, GADD45G, RAD1, RAD17, RAD18, RAD21, RAD51B, RAD9A, RBBP8, REV1, RNF168, RNF8, SMC1A, SUMO1, TOPBP1, XRCC3
Apoptosis
ABL1, ATM, BARD1, BAX, BBC3 (PUMA), BRCA1, CDKN1A (p21CIP1, WAF1), CHEK2 (RAD53), CIB1, CSNK2A2, PPP1R15A (GADD34), PRKDC, RAD21, RAD9A, SIRT1, TP53 (p53), TP73
Cell Cycle
ATM, ATR, ATRIP, CDC25A, CDC25C, CDK7, CDKN1A (p21CIP1, WAF1), CHEK1, CHEK2 (RAD53), DDIT3 (GADD153, CHOP), MAPK12 (p38GAMMA), MCPH1, MDC1, PPM1D, PPP1R15A (GADD34), TP53 (p53), TP73