Target List
WNT Signaling
Canonical WNT Signaling
AES (TLE5, Groucho), APC, AXIN1, AXIN2, BCL9, CSNK1A1, CSNK2A1, CTBP1, CTNNB1, CTNNBIP1 (ICAT), CXXC4, DIXDC1, DKK1, DKK3, DVL1, DVL2, EP300, FRAT1, FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3A, GSK3B, LEF1, LRP5, LRP6, NKD1, PORCN, PYGO1, RUVBL1, SFRP1, SFRP4, SOX17, TCF7, TCF7L1, WIF1, WNT1, WNT10A, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT6, WNT7A, WNT7B, WNT8A
Planar Cell Polarity (PCP)
DAAM1, DVL1, DVL2, MAPK8 (JNK1), NKD1, PRICKLE1, RHOA, RHOU, VANGL2, WNT9A
WNT / Calcium Signaling
FZD2, NFATC1, WNT1, WNT10A, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT9A
WNT Signaling Negative Regulation
APC, AXIN1, AXIN2, BTRC (bTrCP), CCND1, CTBP1, CTNNBIP1 (ICAT), CXXC4, DKK1, DKK3, FBXW11, FBXW4, FRZB (FRP-3), KREMEN1, LRP6, NKD1, NLK, SFRP1, SFRP4, SOX17, TLE1, WIF1
WNT Signaling Target Genes
AXIN2, BTRC (bTrCP), CCN4, CCND1, CCND2, DAB2, FOSL1 (FRA-1), JUN, MMP7, MYC, PITX2, PPARD
Developmental Processes
Cell Fate
CTNNB1, DKK1, WNT1, WNT3, WNT3A
Tissue Polarity
AXIN2, FZD2, FZD3, FZD5, FZD6, VANGL2
Cell Growth & Proliferation
APC, CCN4, CCND1, CCND2, CTBP1, CTNNB1, CTNNBIP1 (ICAT), DAB2, EP300, FGF4, FOSL1 (FRA-1), FOXN1, FZD3, JUN, LRP5, MMP7, MYC, PPARD, WNT3A
Cell Migration
APC, DKK1, LRP5, LRP6, RHOA, WNT1
Cell Cycle
APC, BTRC (bTrCP), CCND1, CCND2, CTNNB1, EP300, FOSL1 (FRA-1), JUN, MYC, RHOA, RHOU, RUVBL1, TCF7L1
Cellular Homeostasis
APC, FZD2, JUN, MYC