Target List
Differentiation & Development
Regulation of Differentiation & Development
AGT, BDNF, CTNNB1, EPHB2, HES1, KLF10, NFKBIA (IκBα, MAD3), PPARA, PTHLH, PTK2 (FAK), RARA, RHOA, RUNX1 (AML1), SHH, TGFB2, TGFBR2
Other Differentiation & Development Genes
BRD2, CEBPB, CREB1, DNAJA1, EMP1, ENG (EVI-1), FN1, IFRD1, MAPK14 (p38ALPHA), MMP2, MYOD1, SNAI1 (SNAIL)
Cell Proliferation & Migration
Regulation of Proliferation & Migration
ACVRL1 (ALK1), AGT, ATF3, BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), BDNF, CDC6, CDKN1B (P27KIP1), CTNNB1, FURIN, HES1, HMOX1, IL10, KLF10, MSX2, MYC, NFKBIA (IκBα, MAD3), PDGFA, PLG, PTGS2 (COX2), PTHLH, PTK2B (PYK2), SERPINE1 (PAI-1), SHH, SOX4, TGFB2, TGFBR2, THBS1 (TSP-1), TXNIP, VEGFA
Other Cell Proliferation & Migration Genes
ACTA2 (α-SMA), ACVR1 (ALK2), AR, EMP1, FN1, FURIN, IL10, PTK2 (FAK)
Apoptosis
ACVR1 (ALK2), AGT, AIPL1, CDKN1B (P27KIP1), CREB1, CTNNB1, FURIN, GADD45B, HERPUD1, KLF10, MAP3K7 (TAK1), MAPK8 (JNK1), MSX2, PLG, PTGS2 (COX2), RAD21, RHOA, RHOB, RYBP, S100A8, SHH, SOX4, TGFB2, TNFSF10 (TRAIL), TXNIP
Anti-Apoptotic
BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), BDNF, CEBPB, CRYAB, HMOX1, IL10, NFKBIA (IκBα, MAD3), PTK2B (PYK2), THBS1 (TSP-1), VEGFA
Cell Cycle
Regulation of the Cell Cycle
ACVR1 (ALK2), RAD21
Other Cell Cycle Genes
CDC6, CDKN1B (P27KIP1), GADD45B, PTGS2 (COX2), RHOB, TGFB2
Signal Transduction
TGFβ Signaling
ACVR1 (ALK2), ACVRL1 (ALK1), CREBBP (CBP), E2F4, ENG (EVI-1), EP300, ID1, ID2, ID3, MSX2, RBL1, SMAD1 (MADH1), SMAD3 (MADH3), SMAD5 (MADH5), SMAD6, SP1, TGFB2, TGFBR2, THBS1 (TSP-1)
NFκB Signaling
HMOX1, IL10, MAP3K7 (TAK1), NFKBIA (IκBα, MAD3), RHOA, TNFSF10 (TRAIL)
Notch Signaling
HES1, HEY1, NOTCH1
Hedgehog Signaling
GLI2, SHH
WNT Signaling
CTNNB1
Transcription Factors
TGFβ Signaling
CREBBP (CBP), E2F4, EP300, ID1, ID2, ID3, RBL1, SMAD1 (MADH1), SMAD3 (MADH3), SMAD5 (MADH5), SMAD6, SP1
Other Transcription Factors
AR, ATF3, ATF4, BACH1, BHLHE40 (DEC1), CEBPB, CREB1, CTNNB1, FOS, GTF2I, HEY1, KLF10, MBD1, MSX2, MYC, MYOD1, NFIB, PPARA, RARA, RUNX1 (AML1), SOX4, SREBF2