Target List
JAK / STAT Signaling
Janus Kinases
JAK1, JAK2, JAK3, TYK2
STAT Family Members
STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6
JAK / STAT Signaling Regulators
PIAS1, PIAS2, PRL, PTPN1 (PTP1B), PTPRC, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5
Cell Surface Receptors
CSF1R, EGFR (ERBB1), EPOR, F2R (PAR1), GHR, IFNAR1, IFNGR1, IL10RA, IL2RA (CD25), IL2RG, IL4R (CD124), IL6ST (GP130), INSR, MPL, PDGFRA, SH2B1
SH3 / SH2 Adaptor Proteins
CRK, GRB2, SRC, STAM
STAT-Interacting Transcription Factors & Regulators
Transcriptional Regulation
HMGA1, SMAD3 (MADH3), SPI1
Transcription Factors
JUNB, SP1, USF1
Transcriptional Coactivators & Corepressors
JUNB, PIAS1, SMAD1 (MADH1), SMAD5 (MADH5), SP1, YY1
Other Transcription Factors & Regulators
CEBPB, CRK, GATA3, IRF1, IRF9, JUN, MYC, NFKB1, NR3C1 (GRL), SMAD2 (MADH2), SMAD4 (MADH4)
STAT-Induced
STAT1-Induced
CXCL9 (MIG), IRF1, JUNB, NOS2 (iNOS)
STAT3-Induced
A2M, BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), CCND1, CDKN1A (p21CIP1, WAF1), CEBPD, CRP, FAS, IRF1, LRG1, MCL1, MYC, SOCS1, SOCS3
STAT4-Induced
FCGR1A, IFNG, IRF1, MYC
STAT5-Induced
BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), CCND1, CDKN1A (p21CIP1, WAF1), IL2RA (CD25), IRF1, OSM
STAT6-Induced
FCER2, GATA3, IL4, IL4R (CD124)
STAT1 / STAT2 / p48 Induced
ISG15, OAS1
Apoptosis
AKT1, BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), CDKN1A (p21CIP1, WAF1), F2 (Thrombin), F2R (PAR1), FAS, IL2RA (CD25), MCL1, NFKB1, PRLR, STAT1
Cell Growth and / or Maintenance
Cell Cycle
CCND1, CDKN1A (p21CIP1, WAF1), EGFR (ERBB1), F2 (Thrombin), F2R (PAR1), IL2RA (CD25), IRF1, JAK2, MYC, STAT1
Cell Growth
A2M, EGFR (ERBB1), GHR, IFNG, IL4, INSR, OSM, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5
Cell Proliferation
CSF1R, IL2RG, IL4, MPL, OSM, PDGFRA, SMAD3 (MADH3)
Cell Differentiation
IL20, IL4, NOS2 (iNOS), SOCS2, SOCS5
Immune Response
Acute-Phase Response
CEBPB, CRP, F2 (Thrombin), STAT3
Humoral Immune Response
CSF1R, FCER2, IL4, NFKB1, YY1
Inflammatory Response
CEBPB, CRP, CXCL9 (MIG), IL20, NFKB1, NOS2 (iNOS), NR3C1 (GRL)
Other Immune Response Genes
CXCL9 (MIG), FAS, FCGR1A, IFNG, IL2RA (CD25), IL2RG, IL4R (CD124), IL6ST (GP130), IRF1, IRF9, ISG15, OAS1, OSM, PRLR, PTPN11, STUB1