Target List
MYC & Co-Transcription Factors
E2F1, MAX, MAZ, MYCL, MYCN, PIAS2
Up-Regulated by MYC
AIMP2, APEX1, ATF4, BAX, BCAT1, CAD, CBX3, CCNB1, CCND2, CCT5, CDC25A, CDK4, CHEK1, CKS2, CSTB, CTSC, DDX10, DKC1, E2F1, EIF4A1, EIF4B, EIF4E, ENO1, EXOSC8, FASN, GNL3, HK2, HNRNPA1, HNRNPA2B1, LTA4H, MAT2A, MGST1, MSH2, MTHFD1, NAP1L1, NBN, NCL, NME1 (NM23), NOLC1, NPM1, ODC1, PA2G4, PAICS, PCNA, PHB, POLD2, PPAT, PSMG1, PTEN, PYCR1, RPL13, RPL19, RPL23, RPL27A, RPL5, RPS5, SHMT1, SNRPB, SRM, SRSF1, TERT, TOP1, TP53 (p53), TPI1, TYMS, UBE2C, YBX3
Down-Regulated by MYC
CDKN1B (P27KIP1), CDKN2B (p15INK4b), CSDE1, ID3, ILK, ITGB1, MYC, PTPA, ZFP36L1
Apoptosis
BAX, CCNB1, GNL3, NPM1, TP53 (p53)
Cell Cycle
CCNB1, CCND2, CDC25A, CDK4, CDKN1B (P27KIP1), CDKN2B (p15INK4b), GNL3, PA2G4, PCNA, TP53 (p53)
Cell Growth & Proliferation
CDKN1B (P27KIP1), CKS2, NPM1, PA2G4, PCNA, PHB
Chromatin Modifying & Associated Proteins
CBX3, NAP1L1
DNA Repair
AIMP2, APEX1, CHEK1, MSH2, NBN, NPM1, PCNA, TERT, TP53 (p53)
DNA Replication
PCNA, POLD2, TOP1
Extracellular Matrix (ECM) & Cell Adhesion Molecules
ILK, ITGB1
Metabolism
BCAT1, CAD, ENO1, FASN, GCLC, HK2, LTA4H, MAT2A, MGST1, MTHFD1, NME1 (NM23), ODC1, PAICS, PDK1, PPAT, PYCR1, SHMT1, SRM, TPI1, TYMS
Protein Synthesis, Degradation & Turnover
CCT5, CSTB, CTSC, EIF4A1, EIF4B, EIF4E, NCL, NPM1, PSMG1, PYCR1, RPL13, RPL19, RPL23, RPL27A, RPL5, RPS5, UBE2C
RNA Processing & Binding Factors
CSDE1, DDX10, DDX39B, DKC1, EXOSC8, HNRNPA1, HNRNPA2B1, NOLC1, SNRPB, SRSF1
Signal Transduction
ILK, NPM1, PDK1, PTEN, PTPA
Transcription Factors & Cofactors
ATF4, ID3, MYC, TP53 (p53), YBX3, ZFP36L1
Tumor Suppressor Genes
MSH2, PHB, TP53 (p53)