Target List
Drug Resistance
ABCB1 (MDR1, PGY1), ABCC1 (MRP1), ABCC2 (MRP2, cMOAT), ABCC3 (MRP3, MOAT-D), ABCC5 (MRP5), ABCG2 (BCRP), BAX, BCL2, BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), MVP (LRP), RB1, TOP1, TOP2A, TOP2B, TP53 (p53)
Drug Metabolism
ARNT, BLMH, CLPTM1L, CYP1A1, CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4, CYP3A5, DHFR, EPHX1, GSK3A, GSTP1, NAT2, SOD1, SULT1E1, TPMT, UGCG
DNA Damage & Repair
APC, ATM, BRCA1, BRCA2, ERCC3 (XPB), MSH2, XPA, XPC
Cell Cycle
CCND1, CCNE1, CDK2, CDK4, CDKN1A (p21CIP1, WAF1), CDKN1B (P27KIP1), CDKN2A (P16INK4A), CDKN2D (p19-INK4D)
Growth Factor Receptors
EGFR (ERBB1), ERBB2 (HER-2, NEU), ERBB3, ERBB4, FGF2 (BFGF), IGF1R, IGF2R, MET
Hormone Receptors
AR, ESR1 (ERα), ESR2 (ERβ), PPARA, PPARD, PPARG, RARA, RARB, RARG, RXRA, RXRB
Transcription Factors
AHR, AP1S1, ELK1, FOS, HIF1A, MYC, NFKB1, NFKB2, NFKBIB (TRIP9), NFKBIE, RELB, TNFRSF11A (RANK)