Target List
Skeletal Muscle Contractility
Dystrophin-Glycoprotein Complex
CAMK2G, CAPN3, CAV3, DAG1, DMD, DYSF, LMNA, MAPK1 (ERK2), SGCA
Titin Complex
ACTA1, ACTN3, CAPN3, CRYAB, DES, LMNA, MAPK1 (ERK2), MSTN, MYH1, MYH2, MYOT, NEB, SGCA, TNNI2, TNNT1, TNNT3, TRIM63 (MURF1), TTN
Energy Metabolism
CS, HK2, PDK4, SLC2A4 (GLUT4)
Fast-Twitch Fibers
ATP2A1, MYH1, MYH2, TNNI2, TNNT3
Slow-Twitch Fibers
MB, MYH1, TNNC1, TNNT1
Other Skeletal Muscle Contractility Genes
DMPK, IKBKB (IKKβ), RPS6KB1
Skeletal Myogenesis
ACTA1, ADRB2, AGRN, BCL2, BMP4, CAPN2, CAST, CAV1, CTNNB1, DMD, HDAC5, IGF1, IGFBP3, IGFBP5, MEF2C, MSTN, MUSK, MYF5, MYF6, MYOD1, MYOG, PAX3, PAX7, PPP3CA, RHOA, RPS6KB1, UTRN
Skeletal Muscle Hypertrophy
ACTA1, ACVR2B, ADRB2, IGF1, IGFBP5, MSTN, MYF6, MYOD1, RPS6KB1
Skeletal Muscle Autocrine Signaling
ADIPOQ (ACRP30), FGF2 (BFGF), IGF1, IGF2, IL6, LEP (Leptin), MSTN, TGFB1
Diabetes / Metabolic Syndrome
ADIPOQ (ACRP30), LEP (Leptin), PPARG, PPARGC1A (PGC-1α), PPARGC1B (PGC-1β), PRKAA1 (AMPK), PRKAB2, PRKAG1, PRKAG3, SLC2A4 (GLUT4)
Skeletal Muscle Wasting / Atrophy
Autophagy
CAPN2, CASP3, FBXO32, FOXO1, FOXO3, MSTN, NOS2 (iNOS), PPARGC1A (PGC-1α), PPARGC1B (PGC-1β), RPS6KB1, TRIM63 (MURF1)
Dystrophy
AKT1, AKT2, FBXO32, IL1B, MAPK1 (ERK2), MAPK14 (p38ALPHA), MAPK3 (ERK1), MAPK8 (JNK1), MMP9, NFKB1, TNF, TRIM63 (MURF1), UTRN