Target List
Cell Fate Commitment
DKK1, HES1, HES5, JAG1, NODAL, NOTCH1, NOTCH3, PAX6, RUNX2, SOX9
Developmental Processes
Embryonic Development
DKK1, EDN1, EFNB1, FOXC1, FOXD3, FOXF1, HES1, HES7, MYF5, NODAL, NOTCH1, PBX1, PCDH8, PDGFRA, PDGFRB, RBPJ, TCF15, VEGFA, WNT4, WNT5A
Muscle Development
EDN1, EGR3, FOXC1, HBEGF, HEY2, IGFBP3, JAG1, MYF5, NOTCH1, PDGFB, PDGFRB, TNC
Epidermis Development
JAG1, KRT14, NOTCH1, PTGS2 (COX2), SNAI1 (SNAIL), SOX9, TCF15
Immune System Development
ID2, JAG1, JUN, KITLG (SCF), KITLG (SCF), PBX1, RUNX1 (AML1), SGPL1, VEGFA
Nervous System Development
BDNF, CCND2, DKK1, DTX1, EFNA1, EFNB1, EGR3, FABP7, FOXC1, HES1, HES5, HEY1, HEY2, HEYL, ID3, ID4, JAG1, KALRN, NES, NODAL, NOTCH1, NOTCH3, PAX6, PBX1, RBPJ, RND1, VEGFA
Vasculature Development
EDN1, EFNA1, FLT1 (VEGFR1), FOXC1, FOXF1, HEY2, ID1, JAG1, JUN, NODAL, NOTCH1, RBPJ, RUNX1 (AML1), SGPL1, VEGFA
Kidney Development
ADAMTS1, BDNF, FOXC1, PBX1, PDGFRB, SGPL1
Other Developmental Processes
NRARP, S1PR3
Signal Transduction
Notch Signaling
CREBBP (CBP), DTX1, FOXC1, HES1, HES7, HEY1, HEY2, HEYL, JAG1, LFNG, NOTCH1, NOTCH3, RBPJ, RBPJL, SNW1 (SKIIP)
WNT Signaling
CCND1, DKK1, FRZB (FRP-3), FZD5, CCN4, WNT4, WNT5A, WNT6
Apoptosis
ABL1, BDNF, FOXC1, GADD45B, ID3, IGFBP3, JUN, KALRN, NOTCH1, PTCRA, PTGS2 (COX2), SGPL1, SOCS3, SOX9, VEGFA
Cytokines
CX3CL1, CXCL12 (SDF1), CXCL2 (GRO2, GROb, SCYB2), IL33, NAMPT
Transcription Factors
CBFA2T3, CLOCK, CREBBP (CBP), EGR3, FOXC1, FOXD3, FOXF1, HEY1, HEY2, HEYL, JUN, MSC, MYF5, NOTCH1, PAX6, PBX1, RBPJ, RBPJL, RUNX1 (AML1), RUNX2, SOX9, TCF15
Other Notch Signaling Targets
FJX1, GPSM2, HSPB8, MARK1, RHOV, TEC