PDE4A Gene Summary [Human]
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Details
| Type | Protein Coding |
| Official Symbol | PDE4A |
| Official Name | phosphodiesterase 4A [Source:HGNC Symbol;Acc:HGNC:8780] |
| Ensembl ID | ENSG00000065989 |
| Bio databases IDs | |
| Aliases | phosphodiesterase 4A, phosphodiesterase E2 dunce homolog (Drosophila) |
| Synonyms | D9Ertd60e, DPDE2, Pde2/iva, PDE4, PDE46, Pde4a8, PHOSA, phosphodiesterase 4A, phosphodiesterase 4A, cAMP specific |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDE4A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3'5'-cyclic nucleotide phosphodiesterase
- tryptophan anchoring phosphatidic acid-selective binding domain-1
- arginine rich motif
- arginine proline-rich domain
- 3',5'-cAMP binding
- cAMP-specific phosphodiesterase
- protein domain specific binding
- enzyme
- protein binding
- Phosphodiesterase 4 upstream conserved regions (UCR)
- 3',5'-cyclic-nucleotide phosphodiesterase
Pathways
Biological processes and signaling networks where the PDE4A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary disease
- systemic lupus erythematosus
- obesity
- stroke
- hypertension
- depressive disorder
- pain
- cirrhosis
- hepatic fibrosis
- cancer
role in cell
- phosphorylation in
- expression in
- production in
- differentiation
- apoptosis
- response by
- accumulation in
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- perinuclear region
- cellular membrane
- filamentous network
- Plasma Membrane
- cytosol
- nucleoplasm
- perinuclear space
- nerve ending
- synapse
- perikaryon
- dendrites
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDE4A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- signal transduction
- regulation of protein kinase A signaling cascade
- sensory perception of smell
- cellular response to xenobiotic stimulus
- cAMP catabolic process
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- membrane
- cytosol
- ruffle membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- cAMP binding
- 3',5'-cyclic-GMP phosphodiesterase activity
- 3',5'-cyclic-AMP phosphodiesterase activity