HTR5A Gene Summary [Human]
The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | HTR5A |
| Official Name | 5-hydroxytryptamine receptor 5A [Source:HGNC Symbol;Acc:HGNC:5300] |
| Ensembl ID | ENSG00000157219 |
| Bio databases IDs | |
| Aliases | 5-hydroxytryptamine receptor 5A |
| Synonyms | 5-HT5A, 5-hydroxytryptamine receptor 5A, 5-hydroxytryptamine (serotonin) receptor 5A, Htr5, MR22 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HTR5A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 5-HT1 receptor
- serotonin receptor
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Pathways
Biological processes and signaling networks where the HTR5A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psychosis
- schizophrenia
- bipolar disorder
- agitation
- bipolar I disorder
- post-traumatic stress disorder
- undifferentiated schizophrenia
- schizoaffective disorder
- hebephrenic schizophrenia
- paranoid schizophrenia
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- synaptic membrane
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HTR5A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- adenylate cyclase-inhibiting serotonin receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- response to estradiol stimulus
- synaptic transmission
- hippocampus development
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- dendrite
- perikaryon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serotonin binding
- neurotransmitter receptor activity
- serotonin receptor activity