PCBP1 Gene Summary [Human]
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PCBP1 |
| Official Name | poly(rC) binding protein 1 [Source:HGNC Symbol;Acc:HGNC:8647] |
| Ensembl ID | ENSG00000169564 |
| Bio databases IDs | |
| Aliases | poly(rC) binding protein 1, heterogeneous nuclear ribonucleoprotein E1 |
| Synonyms | [a]CP-1, alphaCP-1, CP1, HEL-S-85, hnRNP-E1, Hnrnp K Like/Sub2.3, hnRNP-X, HNRPE1, HNRPX, poly(rC) binding protein 1, RGD1561319, WBP17, α cp1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PCBP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA binding
- translation activator
- K homology RNA-binding domain
- protein binding
- sequence-specific DNA binding
- metallochaperone
- translation regulator
- RNA binding
- IxI/V motif
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- mRNA 3' UTR binding
- KH domain
- single-stranded DNA binding
- K homology (KH) RNA-binding domain, type I
Pathways
Biological processes and signaling networks where the PCBP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- anemia
- renal clear cell adenocarcinoma
- renal clear cell cancer
- organismal death
- hereditary disorder
- colorectal carcinoma
- colorectal carcinomagenesis
- urothelial bladder carcinoma
- transitional cell bladder cancer
- lung adenocarcinoma formation
role in cell
- molecular cleavage in
- expression in
- upregulation in
- migration
- translation in
- transactivation in
- sphere formation
- epithelial-mesenchymal transition
- invasion by
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytoplasmic ribonucleoprotein granule
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- nuclear speckles
- karyoplast
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PCBP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- postsynaptic density
- extracellular vesicular exosome
- cytoplasm
- nuclear speck
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- cadherin binding
- mRNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- single-stranded DNA binding