Srebf1 Gene Summary [Mouse]
This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. Alternatively spliced transcript variants have been characterized for this gene. [provided by RefSeq, Nov 2017]
Details
| Type | Protein Coding |
| Official Symbol | Srebf1 |
| Official Name | sterol regulatory element binding transcription factor 1 [Source:MGI Symbol;Acc:MGI:107606] |
| Ensembl ID | ENSMUSG00000020538 |
| Bio databases IDs | |
| Aliases | sterol regulatory element binding transcription factor 1 |
| Synonyms | ADD-1, bHLHd1, HMD, IFAP2, S14, SREBP-1, SrebpF1, sterol regulatory element binding transcription factor 1, STEROL RESPONSE ELEMENT |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Srebf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SP repeat domain
- transcription regulator
- membrane-association domain
- transcription activation domain
- transcription factor binding
- chromatin binding
- zDHHC ankyrin repeat binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- basic helix-loop-helix-leucine zipper domain
- ligand-dependent nuclear receptor
- serine phosphorylation site
- helix-loop-helix domain
- Helix-loop-helix DNA-binding domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- protein kinase binding
- DNA binding domain
- nucleic acid binding
- basic Helix Loop Helix (bHLH) domain superfamily
- protein binding
- sequence-specific DNA binding
- DNA binding
- binding protein
- double-stranded DNA binding
- helix loop helix domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Srebf1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- allergic rhinitis
- neoplasia
- obesity
- hyperinsulinism
- IFAP syndrome 2
- breast cancer
- non-insulin-dependent diabetes mellitus
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- hepatocellular carcinoma
regulated by
- beta-estradiol
- DYSF
- lipopolysaccharide
- isobutylmethylxanthine
- valproic acid
- CG
- progesterone
- insulin
- dexamethasone
- thapsigargin
role in cell
- cellular infiltration by
- apoptosis
- phosphorylation in
- production in
- expression in
- number
- formation
- proliferation
- colony formation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- intranuclear region
- perinuclear region
- cellular membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- microsome
- Golgi membrane
- nucleoplasm
- nuclear rim
- nuclear envelope
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Srebf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to food
- insulin secretion
- response to fructose stimulus
- insulin receptor signaling pathway
- response to progesterone stimulus
- response to cAMP
- positive regulation of cholesterol biosynthetic process
- negative regulation of insulin secretion
- response to xenobiotic stimulus
- fat cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- response to ethanol
- response to retinoic acid
- response to glucose stimulus
- cellular response to fatty acid
- lung development
- intracellular receptor mediated signaling pathway
- mRNA transcription from RNA polymerase II promoter
- regulation of heart rate by chemical signal
- cholesterol biosynthetic process
- lipid biosynthetic process
- response to nutrient
- cellular response to starvation
- circadian rhythm
- regulation of transcription from RNA polymerase II promoter
- SREBP-mediated signaling pathway
- regulation of protein stability
- positive regulation of triglyceride biosynthetic process
- lipid metabolic process
- response to glucagon stimulus
- negative regulation of triglyceride metabolic process
- regulation of fatty acid metabolic process
- regulation of lipid storage
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- endoplasmic reticulum membrane
- nucleus
- cytoplasm
- ER to Golgi transport vesicle membrane
- cytosol
- Golgi membrane
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- protein dimerization activity
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- transcription cofactor binding
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- sterol response element binding