Gpc5 Gene Summary [Mouse]
Predicted to be involved in cell migration; positive regulation of canonical Wnt signaling pathway; and regulation of protein localization to membrane. Predicted to be located in plasma membrane. Predicted to be active in cell surface. Is expressed in brain; limb; lower jaw; metanephros; and spinal cord mantle layer. Orthologous to human GPC5 (glypican 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Gpc5 |
| Official Name | glypican 5 [Source:MGI Symbol;Acc:MGI:1194894] |
| Ensembl ID | ENSMUSG00000022112 |
| Bio databases IDs | |
| Aliases | glypican 5 |
| Synonyms | A230034F01Rik, glypican 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpc5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glypican
- ectodomain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometriosis
- epithelial neoplasia
- Alzheimer disease
- COVID-19
- edema
- insomnia
- arthropathy
- breast carcinoma
- nephrosis
- rheumatoid arthritis
role in cell
- proliferation
- growth
- injury
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Golgi lumen
- cell surface
- Extracellular Space
- cellular membrane
- lysosomal compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpc5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of canonical Wnt receptor signaling pathway
- cell migration
Cellular Component
Where in the cell the gene product is active
- membrane
- lysosomal lumen
- Golgi lumen
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding