Xrcc6 Gene Summary [Mouse]
Enables double-stranded DNA binding activity. Involved in positive regulation of lymphocyte differentiation. Acts upstream of or within DNA metabolic process; positive regulation of neurogenesis; and response to ionizing radiation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; gonad; and liver lobe. Orthologous to human XRCC6 (X-ray repair cross complementing 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Xrcc6 |
| Official Name | X-ray repair complementing defective repair in Chinese hamster cells 6 [Source:MGI Symbol;Acc:MGI:95606] |
| Ensembl ID | ENSMUSG00000022471 |
| Bio databases IDs | |
| Aliases | X-ray repair complementing defective repair in Chinese hamster cells 6 |
| Synonyms | CTC75, CTCBF, G22P1, KU70, Kup70, ML8, Thyroid autoantigen 70 kda, TLAA, X-ray repair complementing defective repair in Chinese hamster cells 6, X-ray repair cross complementing 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Xrcc6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ku70/Ku80 C-terminal arm
- acetylation site
- SAP motif
- Ku70/Ku80 beta-barrel domain
- DNA binding domain
- nucleic acid binding
- SAP domain
- nuclear localization sequence
- ATP-dependent DNA helicase II, 70 kDa subunit (ku70)
- enzyme
- protein binding
- DNA dependent ATPase
- sequence-specific DNA binding
- ATPase
- carbon-oxygen lyase
- DNA end binding
- DNA helicase
- cyclin binding
- binding protein
- KU
- double-stranded telomeric DNA binding
- double-stranded DNA binding
- vWFA
- Bax-binding domain
Pathways
Biological processes and signaling networks where the Xrcc6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- pervasive developmental disorder
- epithelial cancer
- epithelial neoplasia
- hypoplasia
- weight gain
- plexiform neurofibroma
- Huntington disease
- liver cancer
role in cell
- accumulation in
- quantity
- proliferation
- phosphorylation in
- expression in
- migration
- apoptosis
- activation in
- production in
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- detergent resistant lipid raft fraction
- secretory granule lumen
- ficolin-1-rich granule lumen
- Cytoplasm
- Extracellular Space
- cellular membrane
- cytosol
- nucleoplasm
- nucleoli
- nuclear envelope
- telomeres
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Xrcc6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- recombinational repair
- positive regulation of lymphocyte differentiation
- DNA ligation
- telomere maintenance
- positive regulation of transcription from RNA polymerase II promoter
- double-strand break repair via nonhomologous end joining
- regulation of smooth muscle cell proliferation
- cellular response to gamma radiation
- cellular response to X-ray
- cellular hyperosmotic salinity response
- negative regulation of transcription, DNA-dependent
- activation of innate immune response
- positive regulation of protein kinase activity
- positive regulation of transcription, DNA-dependent
- DNA duplex unwinding
- innate immune response
Cellular Component
Where in the cell the gene product is active
- DNA-dependent protein kinase complex
- nonhomologous end joining complex
- Ku70:Ku80 complex
- nucleolus
- extracellular region
- nucleoplasm
- nuclear telomere cap complex
- chromosome, telomeric region
- nucleus
- transcription factor complex
- DNA-dependent protein kinase-DNA ligase 4 complex
- membrane
- protein-DNA complex
- cytosol
- secretory granule lumen
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- DNA-dependent ATPase activity
- DNA end binding
- double-stranded DNA binding
- double-stranded telomeric DNA binding
- transcription regulatory region sequence-specific DNA binding
- damaged DNA binding
- scaffold protein binding
- DNA binding
- ATP binding
- DNA helicase activity
- RNA binding
- protein binding
- 5'-deoxyribose-5-phosphate lyase activity
- telomeric DNA binding
- cyclin binding