Cd200 Gene Summary [Mouse]
Predicted to enable protein binding activity involved in heterotypic cell-cell adhesion. Involved in negative regulation of cell population proliferation; negative regulation of macrophage activation; and negative regulation of neuroinflammatory response. Located in cell surface. Is active in postsynaptic density and presynaptic active zone. Is expressed in several structures, including bone; metanephros; nervous system; retina; and skin. Used to study autoimmune disease. Orthologous to human CD200 (CD200 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd200 |
| Official Name | CD200 antigen [Source:MGI Symbol;Acc:MGI:1196990] |
| Ensembl ID | ENSMUSG00000022661 |
| Bio databases IDs | |
| Aliases | CD200 antigen |
| Synonyms | CD200 molecule, Cspmo2, MOX1, MOX2, MRC, MRCOX2, OX-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd200 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- binding protein
- Immunoglobulin V-Type
- immunoglobulin domain
- ectodomain
- cell adhesion molecule binding
- Immunoglobulin like
- protein binding
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Cd200 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- epithelial cancer
- cancer
- metastasis
- advanced cancer
- neoplasia
- glioblastoma cancer
- arthritis
- pneumonitis
- liver cancer
role in cell
- apoptosis
- expression in
- quantity
- proliferation
- differentiation
- activity
- production in
- recruitment
- survival
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- neurites
- synapse
- perikaryon
- axons
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd200 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-6 production
- negative regulation of T cell migration
- negative regulation of macrophage activation
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of cell proliferation
- positive regulation of CREB transcription factor activity
- heterotypic cell-cell adhesion
- negative regulation of leukocyte activation
- positive regulation of transforming growth factor beta production
- regulation of immune response
Cellular Component
Where in the cell the gene product is active
- cell body
- membrane
- neuronal cell body
- neuron projection
- axon
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein binding involved in heterotypic cell-cell adhesion