Ldlrad4 Gene Summary [Mouse]
Predicted to enable R-SMAD binding activity. Involved in negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in Golgi membrane and early endosome membrane. Orthologous to human LDLRAD4 (low density lipoprotein receptor class A domain containing 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ldlrad4 |
| Official Name | low density lipoprotein receptor class A domain containing 4 [Source:MGI Symbol;Acc:MGI:1277150] |
| Ensembl ID | ENSMUSG00000024544 |
| Bio databases IDs | |
| Aliases | low density lipoprotein receptor class A domain containing 4 |
| Synonyms | 8230401C20Rik, A430083H02, A430108L08Rik, C18orf1, D18Ertd653e, D330030L18Rik, low density lipoprotein receptor class A domain containing 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ldlrad4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- LDLa
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- cancer
- side effect
- COVID-19
- non-small cell lung cancer
- acute myeloid leukemia
- idiopathic scoliosis
- Parkinson disease
- gestational diabetes mellitus
- choroidal melanoma
role in cell
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ldlrad4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of epithelial to mesenchymal transition
- negative regulation of SMAD protein import into nucleus
- negative regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- intracellular membrane-bounded organelle
- membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- R-SMAD binding