Cyp26a1 Gene Summary [Mouse]
Enables retinoic acid 4-hydroxylase activity. Involved in cellular response to retinoic acid and retinoic acid catabolic process. Acts upstream of or within anterior/posterior pattern specification; central nervous system development; and neural crest cell development. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; extraembryonic component; and sensory organ. Orthologous to human CYP26A1 (cytochrome P450 family 26 subfamily A member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp26a1 |
| Official Name | cytochrome P450, family 26, subfamily a, polypeptide 1 [Source:MGI Symbol;Acc:MGI:1096359] |
| Ensembl ID | ENSMUSG00000024987 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 26, subfamily a, polypeptide 1 |
| Synonyms | CP26, CYP26, cytochrome P450 family 26 subfamily A member 1, cytochrome P450, family 26, subfamily a, polypeptide 1, P450RA, P450RAI, P450RAI1, RAH, RETINOIC ACID HYDROXYLASE |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cyp26a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- oxygen binding
- binding protein
- retinoic acid 4-hydroxylase
- monooxygenase
- enzyme
- retinoid binding
- NADH2 or NADPH2 1 atom incorporation:oxygen oxidoreductase
Pathways
Biological processes and signaling networks where the Cyp26a1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- organismal death
- exencephaly
- endometriosis
- epithelial cancer
- hyperplasia
- liver cancer
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- dermatitis
regulates
- AKT1
- tretinoin
- alitretinoin
- 4-hydroxy-all-trans-retinoic acid
- 18-hydroxy-retinoic acid
- retinol
- all-trans-4-Oxo-retinoic acid
- xenobiotic
- 5,8-epoxy all-trans retinoic acid
- retinyl palmitate
role in cell
- growth
- differentiation
- development
- cellular infiltration by
- tumorigenicity
- anoikis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cyp26a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to retinoic acid
- kidney development
- xenobiotic metabolic process
- negative regulation of retinoic acid receptor signaling pathway
- retinoic acid metabolic process
- retinoic acid catabolic process
- response to vitamin A
- sterol metabolic process
- vitamin metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- oxygen binding
- retinoic acid binding
- iron ion binding
- retinoic acid 4-hydroxylase activity
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
- monooxygenase activity
- heme binding