Aqp3 Gene Summary [Mouse]
Predicted to enable channel activity; identical protein binding activity; and urea transmembrane transporter activity. Involved in glycerol transmembrane transport and water transport. Acts upstream of or within several processes, including renal water absorption; response to ischemia; and urea transport. Located in basolateral plasma membrane and cell-cell junction. Is expressed in several structures, including alimentary system; capillary; early conceptus; genitourinary system; and sensory organ. Used to study nephrogenic diabetes insipidus. Orthologous to human AQP3 (aquaporin 3 (Gill blood group)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aqp3 |
| Official Name | aquaporin 3 [Source:MGI Symbol;Acc:MGI:1333777] |
| Ensembl ID | ENSMUSG00000028435 |
| Bio databases IDs | |
| Aliases | aquaporin 3 |
| Synonyms | AQP-2, aquaporin 3, aquaporin 3 (Gill blood group), GIL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aqp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MIP
- glycerol channel
- protein binding
- polyol transporter
- identical protein binding
- water channel
- transporter
Pathways
Biological processes and signaling networks where the Aqp3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- contact hypersensitivity
- polyuria
- polydipsia
- rosacea
- irritable bowel syndrome with diarrhea
- colon cancer
- small cell lung cancer
role in cell
- expression in
- migration
- invasion by
- phosphorylation in
- differentiation
- apoptosis
- activation in
- trafficking
- permeability
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- Nucleus
- intercellular junctions
- apical membrane
- basolateral membrane
- basal membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aqp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of keratinocyte differentiation
- renal water homeostasis
- response to vitamin D
- glycerol transport
- urea transmembrane transport
- odontogenesis
- positive regulation of immune system process
- renal water absorption
- water transport
- response to retinoic acid
- response to ischemia
- response to calcium ion
- establishment of localization in cell
- cellular response to hypoxia
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- cytoplasm
- membrane
- basolateral plasma membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- glycerol channel activity
- water channel activity
- urea transmembrane transporter activity