Thsd7a Gene Summary [Mouse]
Involved in actin cytoskeleton organization. Located in plasma membrane and podocyte foot. Is expressed in several structures, including alimentary system; autopod; central nervous system; genitourinary system; and sensory organ. Orthologous to human THSD7A (thrombospondin type 1 domain containing 7A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Thsd7a |
| Official Name | thrombospondin, type I, domain containing 7A [Source:MGI Symbol;Acc:MGI:2685683] |
| Ensembl ID | ENSMUSG00000032625 |
| Bio databases IDs | |
| Aliases | thrombospondin, type I, domain containing 7A |
| Synonyms | Gm837, KIAA0960, RGD1566201, thrombospondin type 1 domain containing 7A, thrombospondin, type I, domain containing 7A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Thsd7a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- protein binding
- Spondin-like TSP1 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tuberculosis
- epithelial ovarian cancer
- ovarian carcinoma
- age-related hearing loss
- coronary artery disease
- IgA nephropathy
- glaucoma
- cataract
- acute myeloid leukemia
- open-angle glaucoma
role in cell
- migration
- phosphorylation in
- formation
- formation in
- effacement
- organization
- tubulation by
- sprouting by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cellular protrusions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Thsd7a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis
- cell differentiation
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- extracellular region
- cell projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding