Cdhr2 Gene Summary [Mouse]
Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in several processes, including cell-cell adhesion mediated by cadherin; intermicrovillar adhesion; and negative regulation of cell growth involved in contact inhibition. Predicted to be located in apical plasma membrane; brush border membrane; and microvillus membrane. Predicted to be active in plasma membrane. Orthologous to human CDHR2 (cadherin related family member 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdhr2 |
| Official Name | cadherin-related family member 2 [Source:MGI Symbol;Acc:MGI:2687323] |
| Ensembl ID | ENSMUSG00000034918 |
| Bio databases IDs | |
| Aliases | cadherin-related family member 2 |
| Synonyms | cadherin-related family member 2, Gm624, PCDH24, PCLCK, PC-LKC, RGD1560576 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdhr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoplasmic domain
- ectodomain
- cell adhesion molecule binding
- Cadherin repeat-like domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- microvilli tips
- brush border
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdhr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- negative regulation of cell growth involved in contact inhibition
- cell-cell adhesion mediated by cadherin
- regulation of microvillus length
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- microvillus membrane
- anchoring junction
- brush border membrane
- extracellular vesicular exosome
- brush border
- microvillus
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- cell adhesion molecule binding