Adamtsl2 Gene Summary [Mouse]
Enables microfibril binding activity. Acts upstream of or within extracellular matrix organization; lobar bronchus epithelium development; and negative regulation of transforming growth factor beta receptor signaling pathway. Located in extracellular matrix and extracellular region. Is expressed in several structures, including cardiovascular system; limb; lung; musculoskeletal system; and tail mesenchyme. Used to study geleophysic dysplasia 1 and impotence. Human ortholog(s) of this gene implicated in geleophysic dysplasia 1. Orthologous to human ADAMTSL2 (ADAMTS like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adamtsl2 |
| Official Name | ADAMTS-like 2 [Source:MGI Symbol;Acc:MGI:1925044] |
| Ensembl ID | ENSMUSG00000036040 |
| Bio databases IDs | |
| Aliases | ADAMTS-like 2 |
| Synonyms | A930008K15Rik, ADAMTS-like 2, GPHYSD1, KIAA0605, LOC100507453, LOC100996396, RGD1305459, tcp-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adamtsl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- ADAM-TS Spacer 1
- PLAC (protease and lacunin) domain
- protein binding
- Spondin-like TSP1 domain
- microfibril binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- aortic stenosis
- epithelial cancer
- liver cancer
- heart failure
- hepatitis B virus-related hepatocellular carcinoma
- dilated cardiomyopathy
- geleophysic dysplasia type 1
- geleophysic dysplasia
- carpal tunnel syndrome
- hypertrophic obstructive cardiomyopathy
role in cell
- expression in
- proliferation
- phosphorylation in
- migration
- organization
- contractility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adamtsl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lobar bronchus epithelium development
- extracellular matrix organization
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- metalloendopeptidase activity
- microfibril binding