Adamts2 Gene Summary [Mouse]
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin repeats) family of proteinases that is involved in the proteolytic processing of procollagens. The encoded protein precursor is proteolytically processed to generate a mature, zinc-dependent enzyme. Mice lacking the encoded protein develop abnormal lungs, fragile skin and male sterility. [provided by RefSeq, Aug 2015]
Details
| Type | Protein Coding |
| Official Symbol | Adamts2 |
| Official Name | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2 [Source:MGI Symbol;Acc:MGI:1347356] |
| Ensembl ID | ENSMUSG00000036545 |
| Bio databases IDs | |
| Aliases | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2 |
| Synonyms | ADAM metallopeptidase with thrombospondin type 1 motif 2, ADAM metallopeptidase with thrombospondin type 1 motif, 2, ADAMTS-3, EDSDERMS, NPI, PC I-NP, PCPNI, PNPI, RGD1565950 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adamts2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- Reprolysin family propeptide
- ADAMTS cysteine-rich domain 2
- ADAMTS cysteine-rich domain
- peptidase
- PLAC (protease and lacunin) domain
- procollagen N-endopeptidase
- metallopeptidase
- ADAM-TS Spacer 1
- ZnMc
- Reprolysin (M12B) family zinc metalloprotease
- Spondin-like TSP1 domain
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Adamts2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dilated cardiomyopathy
- stroke
- COVID-19
- Ehlers-Danlos syndrome type VIIC
- pulmonary emphysema
- idiopathic inflammatory myopathy
- organismal death
- triangular face
- aortic banding-induced cardiac hypertrophy
- soft palate dysplasia
role in cell
- signaling in
- proliferation
- migration
- abnormal morphology
- organization
- transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adamts2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- proteolysis
- extracellular matrix organization
- protein processing
- collagen catabolic process
- collagen fibril organization
- skin development
- lung development
Cellular Component
Where in the cell the gene product is active
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- metalloendopeptidase activity
- metallopeptidase activity