Acvr2b

Enables several functions, including activin binding activity; kinase activator activity; and protein kinase activity. Involved in several processes, including negative regulation of cold-induced thermogenesis; negative regulation of ossification; and vasculature development. Acts upstream of or within several processes, including embryonic morphogenesis; insulin secretion; and regionalization. Predicted to be located in cytoplasm. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; egg cylinder; genitourinary system; nervous system; and sensory organ. Used to study right atrial isomerism and visceral heterotaxy. Human ortholog(s) of this gene implicated in visceral heterotaxy 4. Orthologous to human ACVR2B (activin A receptor type 2B). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acvr2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Acvr2b gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Acvr2b gene, providing context for its role in the cell.