Bglap Gene Summary [Mouse]
This gene encodes one of the most abundant non-collagenous proteins in bone tissue that is localized to the mineralized matrix of bone. The encoded preproprotein undergoes proteolytic processing and post-translational gamma carboxylation to generate a mature, calcium-binding protein. Mice lacking the encoded protein develop abnormalities of bone remodelling. This gene is located adjacent to two other osteocalcin-related genes on chromosome 3. [provided by RefSeq, Oct 2015]
Details
| Type | Protein Coding |
| Official Symbol | Bglap |
| Official Name | bone gamma carboxyglutamate protein [Source:MGI Symbol;Acc:MGI:88156] |
| Ensembl ID | ENSMUSG00000074483 |
| Bio databases IDs | |
| Aliases | bone gamma carboxyglutamate protein |
| Synonyms | Bglap1, Bglap2, BGP, Bgpr, Bgpra, bone gamma-carboxyglutamate protein, Bone Gla-protein, bone γ-carboxyglutamate protein, mOC-A, OC, OCN, OG1, Osteocalcin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bglap often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- structural constituent of bone
- calcium ion binding
- hormone
- protein binding
- Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
- transition metal ion binding
Pathways
Biological processes and signaling networks where the Bglap gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic renal failure
- hypertension
- neoplasia
- Monckeberg sclerosis
- degenerative mitral valve disease
- osteoblastic osteosarcoma
- osteosarcomagenesis
- insulin resistance
- sickle cell anemia
- aortic valve calcification
role in cell
- expression in
- phosphorylation in
- differentiation
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- Cytoplasm
- vesicles
- endoplasmic reticulum lumen
- extracellular matrix
- cellular protrusions
- perikaryon
- dendrites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bglap gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to zinc ion
- response to vitamin D
- response to estrogen stimulus
- response to vitamin K
- regulation of cellular response to insulin stimulus
- cell adhesion
- regulation of bone resorption
- response to xenobiotic stimulus
- response to mechanical stimulus
- learning or memory
- bone development
- cellular response to insulin stimulus
- response to gravity
- response to ethanol
- skeletal system development
- stem cell differentiation
- cognition
- type B pancreatic cell proliferation
- regulation of osteoclast differentiation
- response to glucocorticoid stimulus
- osteoblast differentiation
- cellular response to zinc ion starvation
- response to testosterone stimulus
- response to macrophage colony-stimulating factor stimulus
- dephosphorylation
- regulation of bone mineralization
- bone mineralization
- response to hydroxyisoflavone
- signal transduction
- osteoblast development
- brain development
- cellular response to growth factor stimulus
- positive regulation of neurotransmitter secretion
- glucose homeostasis
- response to activity
- cellular response to vitamin D
- regulation of testosterone biosynthetic process
Cellular Component
Where in the cell the gene product is active
- dendrite
- endoplasmic reticulum lumen
- extracellular space
- cytoplasm
- vesicle
- Golgi lumen
- extracellular region
- perikaryon
Molecular Function
What the gene product does at the molecular level
- hydroxyapatite binding
- protein binding
- calcium ion binding
- structural molecule activity
- structural constituent of bone
- hormone activity