IL-15 Signaling
Interleukin 15 (IL-15) belongs to the 4-α-helix bundle family of glycoprotein cytokines that include IL-2, IL-3, IL-4 and IL-21. It exerts profounds effects on the proliferation, survival and differentiation of NK cells and T cells. IL-15 signaling is mainly mediated via a transmembrane heterotrimeric receptor complex that consists of a high affinity ligand binding subunit IL-15Rα and -β and -γ signal transducing subunits. The latter two it shares with IL-2. IL-15 can also signal via an intermediate affinity receptor...
Pathway Summary
Interleukin 15 (IL-15) belongs to the 4-α-helix bundle family of glycoprotein cytokines that include IL-2, IL-3, IL-4 and IL-21. It exerts profounds effects on the proliferation, survival and differentiation of NK cells and T cells. IL-15 signaling is mainly mediated via a transmembrane heterotrimeric receptor complex that consists of a high affinity ligand binding subunit IL-15Rα and -β and -γ signal transducing subunits. The latter two it shares with IL-2. IL-15 can also signal via an intermediate affinity receptor. Mast cells use a unique receptor, IL-15RX, to mediate signal transduction. IL-15 activates various signaling pathways in different cell types including the JAK/STAT, MAPK and NF-κB pathways to control cell growth and differentiation, enhance phagocytosis and increase the inflammatory response.IL-15 uses juxtacrine and reverse signaling mechanisms in certain cell types, since its major form is membrane-bound, not soluble. For example, reverse signaling occurs in monocytes when the membrane-bound IL-15 is stimulated with soluble IL-15Rα or anti-IL-15 Abs, which can result in activation of ERK, p38MAPK or FAK pathways. In juxtacrine signaling, monocyte membrane-bound IL-15 binds to the receptor complex on neighboring T-cells and initiates signal transduction. (Upgraded 01/2020)
IL-15 Signaling Genes list
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AKT1AKT serine/threonine kinase 1 AKT1S1AKT1 substrate 1 AKT2AKT serine/threonine kinase 2 AKT3AKT serine/threonine kinase 3 CSF2colony stimulating factor 2 CXCL8C-X-C motif chemokine ligand 8 ERASES cell expressed Ras GNB1LG protein subunit beta 1 like GZMBgranzyme B HRASHRas proto-oncogene, GTPase IGHA1immunoglobulin heavy constant alpha 1 IGHA2immunoglobulin heavy constant alpha 2 (A2m marker) IGHDimmunoglobulin heavy constant delta IGHD1-1immunoglobulin heavy diversity 1-1 IGHD1-14immunoglobulin heavy diversity 1-14 (non-functional) IGHD1-20immunoglobulin heavy diversity 1-20 IGHD1-26immunoglobulin heavy diversity 1-26 IGHD1-7immunoglobulin heavy diversity 1-7 IGHD2-15immunoglobulin heavy diversity 2-15 IGHD2-2immunoglobulin heavy diversity 2-2 IGHD2-21immunoglobulin heavy diversity 2-21 IGHD2-8immunoglobulin heavy diversity 2-8 IGHD3-10immunoglobulin heavy diversity 3-10 IGHD3-16immunoglobulin heavy diversity 3-16 IGHD3-22immunoglobulin heavy diversity 3-22 IGHD3-3immunoglobulin heavy diversity 3-3 IGHD3-9immunoglobulin heavy diversity 3-9 IGHD4-11immunoglobulin heavy diversity 4-11 (non-functional) IGHD4-17immunoglobulin heavy diversity 4-17 IGHD4-23immunoglobulin heavy diversity 4-23 (non-functional) IGHD4-4immunoglobulin heavy diversity 4-4 IGHD5-12immunoglobulin heavy diversity 5-12 IGHD5-18immunoglobulin heavy diversity 5-18 IGHD5-24immunoglobulin heavy diversity 5-24 (non-functional) IGHD5-5immunoglobulin heavy diversity 5-5 IGHD6-13immunoglobulin heavy diversity 6-13 IGHD6-19immunoglobulin heavy diversity 6-19 IGHD6-25immunoglobulin heavy diversity 6-25 IGHD6-6immunoglobulin heavy diversity 6-6 IGHD7-27immunoglobulin heavy diversity 7-27 IGHEimmunoglobulin heavy constant epsilon IGHG1immunoglobulin heavy constant gamma 1 (G1m marker) IGHG2immunoglobulin heavy constant gamma 2 (G2m marker) IGHG3immunoglobulin heavy constant gamma 3 (G3m marker) IGHG4immunoglobulin heavy constant gamma 4 (G4m marker) IGHJ1immunoglobulin heavy joining 1 IGHJ2immunoglobulin heavy joining 2 IGHJ3immunoglobulin heavy joining 3 IGHJ4immunoglobulin heavy joining 4 IGHJ5immunoglobulin heavy joining 5 IGHJ6immunoglobulin heavy joining 6 IGHMimmunoglobulin heavy constant mu IGHV1-12immunoglobulin heavy variable 1-12 (pseudogene) IGHV1-18immunoglobulin heavy variable 1-18 IGHV1-2immunoglobulin heavy variable 1-2 IGHV1-24immunoglobulin heavy variable 1-24 IGHV1-3immunoglobulin heavy variable 1-3 IGHV1-45immunoglobulin heavy variable 1-45 IGHV1-46immunoglobulin heavy variable 1-46 IGHV1-58immunoglobulin heavy variable 1-58 IGHV1-67immunoglobulin heavy variable 1-67 (pseudogene) IGHV1-69immunoglobulin heavy variable 1-69 IGHV1-69-2immunoglobulin heavy variable 1-69-2 IGHV1-69Dimmunoglobulin heavy variable 1-69D IGHV2-26immunoglobulin heavy variable 2-26 IGHV2-5immunoglobulin heavy variable 2-5 IGHV2-70immunoglobulin heavy variable 2-70 IGHV2-70Dimmunoglobulin heavy variable 2-70D IGHV3-11immunoglobulin heavy variable 3-11 IGHV3-13immunoglobulin heavy variable 3-13 IGHV3-15immunoglobulin heavy variable 3-15 IGHV3-16immunoglobulin heavy variable 3-16 (non-functional) IGHV3-20immunoglobulin heavy variable 3-20 IGHV3-21immunoglobulin heavy variable 3-21 IGHV3-23immunoglobulin heavy variable 3-23 IGHV3-30immunoglobulin heavy variable 3-30 IGHV3-33immunoglobulin heavy variable 3-33 IGHV3-35immunoglobulin heavy variable 3-35 (non-functional) IGHV3-38immunoglobulin heavy variable 3-38 (non-functional) IGHV3-43immunoglobulin heavy variable 3-43 IGHV3-48immunoglobulin heavy variable 3-48 IGHV3-49immunoglobulin heavy variable 3-49 IGHV3-53immunoglobulin heavy variable 3-53 IGHV3-6immunoglobulin heavy variable 3-6 (pseudogene) IGHV3-64immunoglobulin heavy variable 3-64 IGHV3-64Dimmunoglobulin heavy variable 3-64D IGHV3-66immunoglobulin heavy variable 3-66 IGHV3-7immunoglobulin heavy variable 3-7 IGHV3-72immunoglobulin heavy variable 3-72 IGHV3-73immunoglobulin heavy variable 3-73 IGHV3-74immunoglobulin heavy variable 3-74 IGHV4-28immunoglobulin heavy variable 4-28 IGHV4-34immunoglobulin heavy variable 4-34 IGHV4-39immunoglobulin heavy variable 4-39 IGHV4-4immunoglobulin heavy variable 4-4 IGHV4-59immunoglobulin heavy variable 4-59 IGHV4-61immunoglobulin heavy variable 4-61 IGHV5-51immunoglobulin heavy variable 5-51 IGHV6-1immunoglobulin heavy variable 6-1 IGHV7-4-1immunoglobulin heavy variable 7-4-1 IGHV7-81immunoglobulin heavy variable 7-81 (non-functional) IGKCimmunoglobulin kappa constant IGKJ1immunoglobulin kappa joining 1 IGKJ2immunoglobulin kappa joining 2 IGKJ3immunoglobulin kappa joining 3 IGKJ4immunoglobulin kappa joining 4 IGKJ5immunoglobulin kappa joining 5 IGKV1-12immunoglobulin kappa variable 1-12 IGKV1-16immunoglobulin kappa variable 1-16 IGKV1-17immunoglobulin kappa variable 1-17 IGKV1-27immunoglobulin kappa variable 1-27 IGKV1-33immunoglobulin kappa variable 1-33 IGKV1-35immunoglobulin kappa variable 1-35 (pseudogene) IGKV1-37immunoglobulin kappa variable 1-37 (non-functional) IGKV1-39immunoglobulin kappa variable 1-39 IGKV1-5immunoglobulin kappa variable 1-5 IGKV1-6immunoglobulin kappa variable 1-6 IGKV1-8immunoglobulin kappa variable 1-8 IGKV1-9immunoglobulin kappa variable 1-9 IGKV1D-12immunoglobulin kappa variable 1D-12 IGKV1D-13immunoglobulin kappa variable 1D-13 IGKV1D-16immunoglobulin kappa variable 1D-16 IGKV1D-17immunoglobulin kappa variable 1D-17 IGKV1D-33immunoglobulin kappa variable 1D-33 IGKV1D-37immunoglobulin kappa variable 1D-37 (non-functional) IGKV1D-39immunoglobulin kappa variable 1D-39 IGKV1D-42immunoglobulin kappa variable 1D-42 (non-functional) IGKV1D-43immunoglobulin kappa variable 1D-43 IGKV1D-8immunoglobulin kappa variable 1D-8 IGKV2-24immunoglobulin kappa variable 2-24 IGKV2-28immunoglobulin kappa variable 2-28 IGKV2-30immunoglobulin kappa variable 2-30 IGKV2-40immunoglobulin kappa variable 2-40 IGKV2D-24immunoglobulin kappa variable 2D-24 (non-functional) IGKV2D-26immunoglobulin kappa variable 2D-26 IGKV2D-28immunoglobulin kappa variable 2D-28 IGKV2D-29immunoglobulin kappa variable 2D-29 IGKV2D-30immunoglobulin kappa variable 2D-30 IGKV2D-40immunoglobulin kappa variable 2D-40 IGKV3-11immunoglobulin kappa variable 3-11 IGKV3-15immunoglobulin kappa variable 3-15 IGKV3-20immunoglobulin kappa variable 3-20 IGKV3-7immunoglobulin kappa variable 3-7 (non-functional) IGKV3D-11immunoglobulin kappa variable 3D-11 IGKV3D-15immunoglobulin kappa variable 3D-15 IGKV3D-20immunoglobulin kappa variable 3D-20 IGKV3D-7immunoglobulin kappa variable 3D-7 IGKV4-1immunoglobulin kappa variable 4-1 IGKV5-2immunoglobulin kappa variable 5-2 IGKV6-21immunoglobulin kappa variable 6-21 (non-functional) IGKV6D-21immunoglobulin kappa variable 6D-21 (non-functional) IGKV6D-41immunoglobulin kappa variable 6D-41 (non-functional) IGLC1immunoglobulin lambda constant 1 IGLC2immunoglobulin lambda constant 2 IGLC3immunoglobulin lambda constant 3 (Kern-Oz+ marker) IGLC4immunoglobulin lambda constant 4 (pseudogene) IGLC7immunoglobulin lambda constant 7 IGLJ1immunoglobulin lambda joining 1 IGLJ2immunoglobulin lambda joining 2 IGLJ3immunoglobulin lambda joining 3 IGLJ4immunoglobulin lambda joining 4 (non-functional) IGLJ5immunoglobulin lambda joining 5 (non-functional) IGLJ6immunoglobulin lambda joining 6 IGLJ7immunoglobulin lambda joining 7 IGLV1-36immunoglobulin lambda variable 1-36 IGLV1-40immunoglobulin lambda variable 1-40 IGLV1-44immunoglobulin lambda variable 1-44 IGLV1-47immunoglobulin lambda variable 1-47 IGLV1-50immunoglobulin lambda variable 1-50 (non-functional) IGLV1-51immunoglobulin lambda variable 1-51 IGLV10-54immunoglobulin lambda variable 10-54 IGLV11-55immunoglobulin lambda variable 11-55 (non-functional) IGLV2-11immunoglobulin lambda variable 2-11 IGLV2-14immunoglobulin lambda variable 2-14 IGLV2-18immunoglobulin lambda variable 2-18 IGLV2-23immunoglobulin lambda variable 2-23 IGLV2-33immunoglobulin lambda variable 2-33 (non-functional) IGLV2-8immunoglobulin lambda variable 2-8 IGLV3-1immunoglobulin lambda variable 3-1 IGLV3-10immunoglobulin lambda variable 3-10 IGLV3-12immunoglobulin lambda variable 3-12 IGLV3-16immunoglobulin lambda variable 3-16 IGLV3-19immunoglobulin lambda variable 3-19 IGLV3-21immunoglobulin lambda variable 3-21 IGLV3-22immunoglobulin lambda variable 3-22 IGLV3-25immunoglobulin lambda variable 3-25 IGLV3-27immunoglobulin lambda variable 3-27 IGLV3-32immunoglobulin lambda variable 3-32 (non-functional) IGLV3-9immunoglobulin lambda variable 3-9 IGLV4-3immunoglobulin lambda variable 4-3 IGLV4-60immunoglobulin lambda variable 4-60 IGLV4-69immunoglobulin lambda variable 4-69 IGLV5-37immunoglobulin lambda variable 5-37 IGLV5-45immunoglobulin lambda variable 5-45 IGLV5-48immunoglobulin lambda variable 5-48 (non-functional) IGLV5-52immunoglobulin lambda variable 5-52 IGLV6-57immunoglobulin lambda variable 6-57 IGLV7-43immunoglobulin lambda variable 7-43 IGLV7-46immunoglobulin lambda variable 7-46 IGLV8-61immunoglobulin lambda variable 8-61 IGLV9-49immunoglobulin lambda variable 9-49 IL15interleukin 15 IL15RAinterleukin 15 receptor subunit alpha IL17Ainterleukin 17A IL2RBinterleukin 2 receptor subunit beta IL2RGinterleukin 2 receptor subunit gamma IL4interleukin 4 JAK1Janus kinase 1 JAK2Janus kinase 2 JAK3Janus kinase 3 KRASKRAS proto-oncogene, GTPase LCKLCK proto-oncogene, Src family tyrosine kinase MAP2K1mitogen-activated protein kinase kinase 1 MAP2K2mitogen-activated protein kinase kinase 2 MAPK1mitogen-activated protein kinase 1 MAPK11mitogen-activated protein kinase 11 MAPK12mitogen-activated protein kinase 12 MAPK13mitogen-activated protein kinase 13 MAPK14mitogen-activated protein kinase 14 MAPK3mitogen-activated protein kinase 3 MLST8MTOR associated protein, LST8 homolog MRASmuscle RAS oncogene homolog MTORmechanistic target of rapamycin kinase MYCMYC proto-oncogene, bHLH transcription factor NFKB1nuclear factor kappa B subunit 1 NFKB2nuclear factor kappa B subunit 2 NRASNRAS proto-oncogene, GTPase PIK3C2Aphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha PIK3C2Bphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta PIK3C2Gphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma PIK3C3phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CBphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta PIK3CGphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma PIK3R1phosphoinositide-3-kinase regulatory subunit 1 PIK3R2phosphoinositide-3-kinase regulatory subunit 2 PIK3R3phosphoinositide-3-kinase regulatory subunit 3 PIK3R4phosphoinositide-3-kinase regulatory subunit 4 PIK3R5phosphoinositide-3-kinase regulatory subunit 5 PIK3R6phosphoinositide-3-kinase regulatory subunit 6 RAC3Rac family small GTPase 3 RAF1Raf-1 proto-oncogene, serine/threonine kinase RALARAS like proto-oncogene A RALBRAS like proto-oncogene B RAP1ARAP1A, member of RAS oncogene family RAP1BRAP1B, member of RAS oncogene family RAP2ARAP2A, member of RAS oncogene family RAP2BRAP2B, member of RAS oncogene family RASD1ras related dexamethasone induced 1 RASD2RASD family member 2 RELREL proto-oncogene, NF-kB subunit RELARELA proto-oncogene, NF-kB subunit RELBRELB proto-oncogene, NF-kB subunit RPS6KB1ribosomal protein S6 kinase B1 RPS6KB2ribosomal protein S6 kinase B2 RPTORregulatory associated protein of MTOR complex 1 RRASRAS related RRAS2RAS related 2 SHC1SHC adaptor protein 1 STAT3signal transducer and activator of transcription 3 STAT5Asignal transducer and activator of transcription 5A STAT5Bsignal transducer and activator of transcription 5B STAT6signal transducer and activator of transcription 6 SYKspleen associated tyrosine kinase TYK2tyrosine kinase 2
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