Target List
Toll-Like Receptor (TLR) Signaling
Toll-Like Receptors & Cofactors
CD14, LY96 (MD-2), TLR1, TLR2, TLR4, TLR5, TLR6, TLR9
MYD88-Dependent
FADD, IRAK1, IRAK3, IRF5, IRF7, MAP3K7 (TAK1), MYD88, TIRAP, TLR1, TLR2, TLR4, TLR5, TLR6, TLR9, TOLLIP, TRAF6
TICAM1 (TRIF)-Dependent (MYD88-Independent) Signaling
IRF5, IRF7, MAP3K7 (TAK1), RIPK1, TICAM1 (TRIF), TICAM2 (TRAM), TLR4, TRAF6
Other Toll-Like Receptor Signaling Genes
AKT1, CASP8 (FLICE), LBP, PIK3CA (p110-alpha), RAC1
NOD-Like Receptor (NLR) Signaling
NOD-Like Receptors
NAIP, NLRC4 (IPAF), NLRP1, NLRP3, NOD1 (CARD4), NOD2
Inflammasomes
CASP1 (ICE), NAIP, NLRC4 (IPAF), NLRP1, NLRP3, PYCARD (TMS1, ASC)
Regulation of NOD-like Receptor (NLR) Signaling
BIRC3 (c-IAP2), CARD6, CARD9, CASP8 (FLICE), HSP90AA1, MEFV, PSTPIP1, RIPK2, SUGT1, TNF, XIAP
Other Bacterial Pattern Recognition Receptors (PRRs)
APCS, CRP, DMBT1, ZBP1
Signaling Downstream of Antibacterial Responses
NFκB Signaling
CHUK (IKKα), IKBKB (IKKβ), NFKB1, NFKBIA (IκBα, MAD3), RELA, TNFRSF1A (TNFR1)
ERK1 / ERK2 Signaling
JUN, MAP2K1, MAPK1 (ERK2), MAPK3 (ERK1)
JNK / p38 Signaling
JUN, MAP2K3 (MEK3), MAP2K4 (MKK4, JNKK1), MAPK14 (p38ALPHA), MAPK8 (JNK1)
Apoptosis
AKT1, BIRC3 (c-IAP2), CARD6, CARD9, CASP1 (ICE), CASP8 (FLICE), CD14, FADD, IFNB1, IKBKB (IKKβ), IL12A, IL12B, IL1B, IL6, IRAK1, JUN, MAP3K7 (TAK1), MAPK1 (ERK2), MAPK8 (JNK1), MPO, NFKB1, NFKBIA (IκBα, MAD3), PIK3CA (p110-alpha), PYCARD (TMS1, ASC), RAC1, RIPK1, RIPK2, TNF, TNFRSF1A (TNFR1), TRAF6
Inflammatory Response
AKT1, APCS, CCL3 (MIP-1A), CCL5 (RANTES), CD14, CRP, CXCL1 (GRO1, GROa, SCYB1), CXCL2 (GRO2, GROb, SCYB2), IL1B, IL6, CXCL8 (IL8), LBP, LY96 (MD-2), LYZ, MEFV, MYD88, NFKB1, NLRC4 (IPAF), NLRP3, NOD1 (CARD4), RAC1, RELA, RIPK2, SLC11A1, TICAM2 (TRAM), TIRAP, TLR1, TLR2, TLR4, TLR5, TLR6, TLR9, TNF, TNFRSF1A (TNFR1), TOLLIP
Cytokines & Chemokines
CCL3 (MIP-1A), CCL5 (RANTES), CXCL1 (GRO1, GROa, SCYB1), CXCL2 (GRO2, GROb, SCYB2), IFNA1, IFNB1, IL12A, IL12B, IL18, IL1B, IL6, CXCL8 (IL8)
Antimicrobial Peptides
BPI, CAMP, CTSG, LCN2 (NGAL), LTF, LYZ, MPO, PRTN3, SLPI