Slc27a6 Gene Summary [Rat]
Predicted to enable long-chain fatty acid transmembrane transporter activity; long-chain fatty acid-CoA ligase activity; and very long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid import into cell and long-chain fatty acid metabolic process. Predicted to be active in endoplasmic reticulum membrane and plasma membrane. Biomarker of myocardial infarction. Orthologous to human SLC27A6 (solute carrier family 27 member 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc27a6 |
| Official Name | solute carrier family 27 member 6 [Source:RGD Symbol;Acc:1311977] |
| Ensembl ID | ENSRNOG00000058193 |
| Bio databases IDs | |
| Aliases | solute carrier family 27 member 6 |
| Synonyms | 4732438L20, 4732438L20Rik, ACSVL2, FACVL2, FATP-6, LOC100910486, mVLCS-H1, solute carrier family 27 (fatty acid transporter), member 6, solute carrier family 27 member 6, VLACS2, VLCS-H1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc27a6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- fatty-acid ligase
- long-chain-fatty-acid-CoA ligase
- AMP-binding enzyme
- CoA-ligase
- fatty acid transporter
- Adenylate forming domain, Class I superfamily
- O-succinylbenzoate-CoA ligase
- AMP-binding enzyme C-terminal domain
- transporter
Pathways
Biological processes and signaling networks where the Slc27a6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- essential hypertension
- insomnia
- coronary artery disease
- breast cancer
- oral submucous fibrosis
- atrial fibrillation
- ocular sarcoidosis
- Huntington disease
- papillary thyroid cancer
regulates
- MYC
- linoleic acid
- very long chain fatty acid
- C20:4 fatty acid
- long chain fatty acid
- oleic acid
- D-erythro-C24:0-ceramide
- palmitic acid
role in cell
- expression in
- apoptosis
- proliferation
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Endoplasmic Reticulum
- cytoplasmic aggregates
- sarcolemma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc27a6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-chain fatty acid import
- long-chain fatty acid metabolic process
- long-chain fatty acid transport
- very long-chain fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- sarcolemma
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- very long-chain fatty acid-CoA ligase activity
- fatty acid transporter activity
- arachidonate-CoA ligase activity
- long-chain fatty acid-CoA ligase activity
- long-chain fatty acid transporter activity