icon_0328_cc_gen_hmr_bacteria-s

Interferon Signaling

Interferons (IFN) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. They are divided into three classes:Type I (predominantly IFN-α, -β and -κ), Type II (IFN-γ) and Type III (IFN-λ1 and -λ2 also known as IL-28 and IL-29). IFN receptors are transmembrane proteins that function as heterodimers. The Type I IFN receptor is made up of IFNAR1 and IFNAR2 while the type II IFN receptor consists of IFNGR1 and IFNGR2. Type I and Type II IFNs bind to IFNAR1 and IFNGR1 respectively while IFNAR2 and IFNGR2 subunits are involved in signal transduction...

Interferon Signaling

Pathway Summary

Interferons (IFN) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. They are divided into three classes:Type I (predominantly IFN-α, -β and -κ), Type II (IFN-γ) and Type III (IFN-λ1 and -λ2 also known as IL-28 and IL-29). IFN receptors are transmembrane proteins that function as heterodimers. The Type I IFN receptor is made up of IFNAR1 and IFNAR2 while the type II IFN receptor consists of IFNGR1 and IFNGR2. Type I and Type II IFNs bind to IFNAR1 and IFNGR1 respectively while IFNAR2 and IFNGR2 subunits are involved in signal transduction. IFNAR2 and IFNGR2 activate tyrosine kinases JAK1, JAK2 or TYK2 which in turn phosphorylate the STAT proteins. STATs dimerize and translocate to the nucleus. In the case to Type I IFNs, STAT1-STAT2 heterodimers associate with IFN gene regulatory factor-9 (IRF-9). The resultant trimeric transcription factor, ISGF3, binds to the IFN-stimulated regulatory elements (ISREs) to induce the expression of many IFN-α/β-regulated genes. For Type II IFNs, STAT1 dimers bind to the γ-IFN-activated sequence (GAS) to drive IFN-γ induced gene expression.

Products related to Interferon Signaling

Explore products related to Interferon Signaling
GeneGlobe ID: PAHS-064Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Interferons & Receptors
RT2 Profiler PCR Array
Product Specification
GeneGlobe ID: PAHS-016Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Type I Interferon Response
RT2 Profiler PCR Array
Product Specification
GeneGlobe ID: UPHS-016Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Type I Interferon Response
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: UPHS-064Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Interferons & Receptors
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: SBHS-016Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Type I Interferon Response
QuantiNova LNA PCR Focus Panel
Product Specification
GeneGlobe ID: SBHS-064Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Interferons & Receptors
QuantiNova LNA PCR Focus Panel
Product Specification

Didn't find what you're looking for?

Discover other products relevant to this gene list with our Panel Finder. Check it out.