PLEK2 Gene Summary [Human]
The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement component 1, q subcomponent, B chain (C1QB), this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | PLEK2 |
| Official Name | pleckstrin 2 [Source:HGNC Symbol;Acc:HGNC:19238] |
| Ensembl ID | ENSG00000100558 |
| Bio databases IDs | |
| Aliases | pleckstrin 2 |
| Synonyms | pleckstrin 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLEK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
- DEP
- binding protein
- PH domain
- Pleckstrin homology-like domain
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- anemia
- atherosclerosis
- organismal death
- metastasis
- lung adenocarcinoma
- lung adenocarcinoma formation
- colon epithelial cancer
- hallucinations
- colon carcinoma
role in cell
- proliferation
- number
- migration
- phosphorylation in
- autophagy in
- expression in
- differentiation
- cisplatin resistance
- invasion by
- migratory capacity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLEK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actin cytoskeleton organization
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
- plasma membrane
- lamellipodium membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,5-bisphosphate binding
- phosphatidylinositol-3-phosphate binding
- phosphatidylinositol-3,4-bisphosphate binding