CRIM1 Gene Summary [Human]
This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. [provided by RefSeq, Nov 2010]
Details
| Type | Protein Coding |
| Official Symbol | CRIM1 |
| Official Name | cysteine rich transmembrane BMP regulator 1 [Source:HGNC Symbol;Acc:HGNC:2359] |
| Ensembl ID | ENSG00000150938 |
| Bio databases IDs | |
| Aliases | cysteine rich transmembrane BMP regulator 1 |
| Synonyms | cysteine rich transmembrane BMP regulator 1, S52 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CRIM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Cysteine-rich motor neuron 1 protein C-terminal
- von Willebrand factor type C domain
- insulin-like growth factor receptor
- Insulin-like growth factor binding protein
- Antistasin family
- PDZ-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- edema
- diabetic nephropathy
- hypoplasia
- syndactyly
- neuroblastoma
- neuroblastoma formation
- Huntington disease
- uterine leiomyoma
- leiomyomatosis
regulates
role in cell
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CRIM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of BMP signaling pathway
- nervous system development
- insulin-like growth factor receptor signaling pathway
- negative regulation of osteoblast differentiation
Cellular Component
Where in the cell the gene product is active
- membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- PDZ domain binding
- insulin-like growth factor-activated receptor activity