NEU4 Gene Summary [Human]
The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2009]
Details
| Type | Protein Coding |
| Official Symbol | NEU4 |
| Official Name | neuraminidase 4 [Source:HGNC Symbol;Acc:HGNC:21328] |
| Ensembl ID | ENSG00000204099 |
| Bio databases IDs | |
| Aliases | neuraminidase 4 |
| Synonyms | 9330166I04, neuraminidase 4, NEWGENE 1308624, sialidase 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NEU4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sialidases/neuraminidases
- Exo-alpha-sialidase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- dextran sodium sulfate-induced colitis
role in cell
- activation in
- outgrowth
- motility
- number
- formation
- growth
- development
- function
- formation in
- outgrowth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- lysosome
- endoplasmic reticulum membrane
- mitochondrial outer membrane
- mitochondrial inner membrane
- lysosomal compartment
- growth cone
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NEU4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycoprotein catabolic process
- negative regulation of neuron projection development
- oligosaccharide catabolic process
- ganglioside catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- membrane
- lysosomal lumen
- mitochondrial outer membrane
- neuron projection
- mitochondrial inner membrane
- plasma membrane
- lysosome
- organelle inner membrane
Molecular Function
What the gene product does at the molecular level
- exo-alpha-(2->6)-sialidase activity
- exo-alpha-(2->8)-sialidase activity
- protein binding
- exo-alpha-sialidase activity
- exo-alpha-(2->3)-sialidase activity