Zfp462 Gene Summary [Mouse]
Predicted to enable DNA binding activity and zinc ion binding activity. Acts upstream of or within chromatin organization and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; ear; genitourinary system; jaw; and limb primordium. Used to study generalized anxiety disorder. Orthologous to human ZNF462 (zinc finger protein 462). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp462 |
| Official Name | zinc finger protein 462 [Source:MGI Symbol;Acc:MGI:107690] |
| Ensembl ID | ENSMUSG00000060206 |
| Bio databases IDs | |
| Aliases | zinc finger protein 462 |
| Synonyms | 6030417H05, 9430078C22Rik, Gt4-2, RGD1562123, WSKA, Zfp462, ZFPIP, zinc finger protein 462 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp462 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Zinc-finger double domain
- C2H2-type zinc-finger domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atrial fibrillation
- familial breast cancer
- Weiss-Kruszka syndrome
- alopecia
- hereditary disorder
- lung adenocarcinoma
- lung adenocarcinoma formation
- headache
- premature ovarian failure
- refractive error
regulates
- RNA polymerase II
- DNA promoter
- DNA endogenous promoter
role in cell
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp462 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin organization
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding