GLUTARYL-COA is a common intermediate in the degradation of many different compounds, such as benzoate and benzoyl-CoA, L-lysine, L-tryptophan and many more. In this pathway glutaryl-CoA is degraded by β-oxidation to 2 molecules of acetyl-CoA and one molecule of CO2
. This pathway can operate under both anaerobic (8436125
) and aerobic conditions (11705404
), although the enzymes catalyzing it may be specialized for either aerobic or anaerobic operation.