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LNA Oligo Optimizer

LNA-enhanced oligonucleotides have different thermodynamic properties from traditional DNA oligonucleotides and will thus fold differently. This tool calculates scores for self-complementarity and secondary structure of an LNA-enhanced oligonucleotide. These scores can be used as a rough estimate of the temperature at which an oligonucleotide will form secondary structure and self-complementarity


Sort by Score
Sort by sequence number
Hybridizations with scores smaller than 0 won't be shown.
Hybridizations with scores bigger than 1000 won't be shown.
Enter DNA bases as uppercase A, C, G, T. Enter locked nucleic acid bases (LNA) as '+' followed by the base (example: +A).
LNA Oligo Optimizer