Il10 Gene Summary [Mouse]
This gene encodes an anti-inflammatory cytokine that is a member of the class-2 cytokine family. The encoded protein is secreted by cells of both the innate and adaptive immune systems and is crucial for limiting the immune response to a broad range of pathogens. It also has been shown to suppress autoimmune responses. This protein mediates it's immunosuppressive signal through a specific interleukin 10 receptor complex. Aberrant functioning of this gene is associated with numerous immune disorders including graft-versus-host disease, and increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | Il10 |
| Official Name | interleukin 10 [Source:MGI Symbol;Acc:MGI:96537] |
| Ensembl ID | ENSMUSG00000016529 |
| Bio databases IDs | |
| Aliases | interleukin 10 |
| Synonyms | CSIF, GVHDS, If2a, IL10A, IL10X, interleukin 10, TGIF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein dimerization
- interleukin-10 receptor binding
- protein binding
- cytokine
- Interleukin 10
Pathways
Biological processes and signaling networks where the Il10 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Airway Inflammation in Asthma
- Allograft Rejection Signaling
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Autoimmune Thyroid Disease Signaling
- Communication between Innate and Adaptive Immune Cells
- Dendritic Cell Maturation
- Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F
- Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F
- Glucocorticoid Receptor Signaling
- Hematopoiesis from Pluripotent Stem Cells
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-10 Signaling
- Neuroinflammation Signaling Pathway
- Role of Cytokines in Mediating Communication between Immune Cells
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Systemic Lupus Erythematosus Signaling
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- anemia
- neoplasia
- idiopathic pulmonary fibrosis
- idiopathic interstitial pneumonia
- prostate cancer
- infection
- pain
- arthritis
- cancer
- Barrett syndrome
phenotypes
- abnormal Langerhans cell physiology
- abnormal bone mineralization
- abnormal bone structure
- abnormal chemokine level
- abnormal circulating enzyme level
- abnormal circulating interleukin-12b level
- abnormal circulating interleukin-6 level
- abnormal circulating protein level
- abnormal circulating serum albumin level
- abnormal colon morphology
- abnormal crypts of Lieberkuhn morphology
- abnormal cytokine level
- abnormal cytokine secretion
- abnormal enterocyte morphology
- abnormal glucose homeostasis
- abnormal homeostasis
- abnormal hypersensitivity reaction
- abnormal immune system physiology
- abnormal inflammatory response
- abnormal innate immunity
- abnormal interferon level
- abnormal interleukin level
- abnormal intestinal epithelium morphology
- abnormal intestinal mucosa morphology
- abnormal intestine physiology
- abnormal iron level
- abnormal large intestine morphology
- abnormal leukocyte morphology
- abnormal level of surface class II molecules
- abnormal lipid level
- abnormal liver physiology
- abnormal lymphocyte cell number
- abnormal myeloid leukocyte morphology
- abnormal myelopoiesis
- abnormal neuron physiology
- abnormal nitric oxide homeostasis
- abnormal osteoblast differentiation
- abnormal placental labyrinth vasculature morphology
- abnormal protein level
- abnormal regulatory T cell physiology
- abnormal reproductive system physiology
- abnormal response to infection
- abnormal skeleton morphology
- abnormal skeleton physiology
- abnormal sleep pattern
- abnormal trabecular bone morphology
- abnormal tumor necrosis factor level
- abnormal type IV hypersensitivity reaction
- absent erythroid progenitor cell
- alveolar process atrophy
- anemia
- cachexia
- cecum inflammation
- chronic inflammation
- colitis
- decreased T cell proliferation
- decreased airway responsiveness
- decreased body weight
- decreased bone mineral content
- decreased bone strength
- decreased bone trabecula number
- decreased circulating cholesterol level
- decreased circulating creatinine level
- decreased circulating insulin level
- decreased circulating interleukin-10 level
- decreased circulating iron level
- decreased compact bone mass
- decreased erythrocyte cell number
- decreased hemoglobin content
- decreased incidence of tumors by UV induction
- decreased length of allograft survival
- decreased mean systemic arterial blood pressure
- decreased physiological sensitivity to xenobiotic
- decreased spleen iron level
- decreased spleen red pulp amount
- decreased susceptibility to induced choroidal neovascularization
- decreased trabecular bone mass
- decreased trabecular bone thickness
- decreased tumor incidence
- decreased vasoconstriction
- enhanced wound healing
- hypochromic anemia
- impaired adaptive thermogenesis
- impaired coordination
- impaired exercise endurance
- increased B cell number
- increased CD4-positive alpha beta T cell number
- increased IgE level
- increased IgG1 level
- increased IgG2a level
- increased T cell number
- increased cerebral infarction size
- increased circulating cholesterol level
- increased circulating interferon-gamma level
- increased circulating interleukin-1 alpha level
- increased circulating interleukin-1 beta level
- increased circulating interleukin-12 level
- increased circulating interleukin-17 level
- increased circulating interleukin-2 level
- increased circulating interleukin-6 level
- increased circulating tumor necrosis factor level
- increased colon adenocarcinoma incidence
- increased fatty acid level
- increased granulocyte number
- increased hepatocyte apoptosis
- increased insulin sensitivity
- increased interferon-gamma secretion
- increased intestinal adenocarcinoma incidence
- increased large intestine adenocarcinoma incidence
- increased leukotriene level
- increased liver triglyceride level
- increased myeloid dendritic cell number
- increased myocardial infarction size
- increased placental labyrinth size
- increased plasma cell number
- increased sensitivity to induced morbidity/mortality
- increased susceptibility to bacterial infection
- increased susceptibility to endotoxin shock
- increased susceptibility to induced colitis
- increased susceptibility to neuronal excitotoxicity
- increased susceptibility to parasitic infection
- increased susceptibility to type IV hypersensitivity reaction
- increased thermal nociceptive threshold
- increased thymus weight
- increased vasoconstriction
- intestinal inflammation
- large intestinal inflammation
- microcytic anemia
- no abnormal phenotype detected
- postnatal growth retardation
- premature death
- rectal prolapse
- short femur
- slow postnatal weight gain
- small intestinal inflammation
- spleen hyperplasia
- thymus hyperplasia
role in cell
- proliferation
- activation in
- phosphorylation in
- expression in
- cell viability
- inhibition in
- growth
- invasion by
- cell death
- cytotoxicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular vesicles
- Cytoplasm
- cell surface
- intracellular space
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-1 production
- cytoplasmic sequestering of NF-kappaB
- positive regulation of sequence-specific DNA binding transcription factor activity
- response to molecule of bacterial origin
- negative regulation of chronic inflammatory response to antigenic stimulus
- positive regulation of transcription, DNA-dependent
- negative regulation of membrane protein ectodomain proteolysis
- chronic inflammatory response to antigenic stimulus
- positive regulation of macrophage activation
- negative regulation of chemokine (C-C motif) ligand 5 production
- positive regulation of immunoglobulin production
- response to carbon monoxide
- negative regulation of cytokine production involved in immune response
- negative regulation of endothelial cell apoptotic process
- negative regulation of interferon-gamma production
- response to inactivity
- negative regulation of interferon-alpha production
- negative regulation of tumor necrosis factor production
- B cell differentiation
- regulation of synapse organization
- negative regulation of inflammatory response
- positive regulation of plasma cell differentiation
- branching involved in labyrinthine layer morphogenesis
- negative regulation of mitotic cell cycle
- B cell proliferation
- defense response to bacterium
- negative regulation of nitric oxide biosynthetic process
- positive regulation of JAK-STAT cascade
- negative regulation of interleukin-6 production
- negative regulation of autophagy
- negative regulation of interleukin-8 production
- regulation of gene expression
- response to activity
- endothelial cell apoptotic process
- negative regulation of cell proliferation
- hemopoiesis
- negative regulation of MHC class II biosynthetic process
- positive regulation of cell cycle
- response to xenobiotic stimulus
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of cytokine activity
- positive regulation of MHC class II biosynthetic process
- defense response to protozoan
- cellular response to estradiol stimulus
- negative regulation of B cell proliferation
- response to insulin stimulus
- response to glucocorticoid stimulus
- regulation of isotype switching
- negative regulation of interleukin-18 production
- negative regulation of myeloid dendritic cell activation
- positive regulation of receptor activity
- type 2 immune response
- cellular response to lipopolysaccharide
- negative regulation of apoptotic process
- negative regulation of T cell proliferation
- cellular response to hepatocyte growth factor stimulus
- positive regulation of heterotypic cell-cell adhesion
- negative regulation of heterotypic cell-cell adhesion
- positive regulation of B cell apoptotic process
- leukocyte chemotaxis
- negative regulation of interleukin-12 production
- positive regulation of endothelial cell proliferation
- negative regulation of cytokine production
- positive regulation of cytokine production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- interleukin-10 receptor binding
- protein dimerization activity
- cytokine activity