Mmp9 Gene Summary [Mouse]
This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that degrades collagens of type IV, V and XI, and elastin. Mice lacking the encoded protein exhibit an abnormal pattern of skeletal growth plate vascularization and ossification, reduced keratinocyte hyperproliferation at all neoplastic stages, a decreased incidence of invasive tumors, and resistance to experimental autoimmune encephalomyelitis. [provided by RefSeq, Feb 2016]
Details
| Type | Protein Coding |
| Official Symbol | Mmp9 |
| Official Name | matrix metallopeptidase 9 [Source:MGI Symbol;Acc:MGI:97011] |
| Ensembl ID | ENSMUSG00000017737 |
| Bio databases IDs | |
| Aliases | matrix metallopeptidase 9 |
| Synonyms | B/MMP9, CLG4B, COLLAGENASE type IV, Gelatinase B, GELB, Gl 92-kda, MANDP2, matrix metallopeptidase 9, METALLOPROTEINASE 9, pro-MMP-9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mmp9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hemopexin-like repeats
- hemopexin C-terminal domain
- hemopexin domain
- peptidase
- enzyme
- identical protein binding
- Putative peptidoglycan binding domain
- zinc ion binding
- gelatinase B
- fibronectin-like domain
- Matrixin
- catalytic domain
- cysteine switch domain
- HX
- PT repeat
- protein binding
- FN2
- fibronectin binding
- metallopeptidase
- blade 1 of the PEX9 domain
- ZnMc
- endopeptidase
- binding protein
- serine endopeptidase
- blade 4 of the PEX9 domain
- collagen binding
- active site
- pro domain
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Mmp9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Airway Inflammation in Asthma
- Airway Pathology in Chronic Obstructive Pulmonary Disease
- Atherosclerosis Signaling
- Axonal Guidance Signaling
- Bladder Cancer Signaling
- Breast Cancer Regulation by Stathmin1
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- Estrogen Receptor Signaling
- FAK Signaling
- Glioma Invasiveness Signaling
- Glucocorticoid Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HIF1α Signaling
- IL-17 Signaling
- IL-8 Signaling
- ILK Signaling
- Inhibition of Angiogenesis by TSP1
- LXR/RXR Activation
- Molecular Mechanisms of Cancer
- Relaxin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- head and neck squamous cell cancer
- rheumatoid arthritis
- psoriasis
- arthritis
- juvenile rheumatoid arthritis
- leukemia
- breast cancer
- osteosarcoma
- lung cancer
phenotypes
- decreased circulating aspartate transaminase level
- short tibia
- abnormal Langerhans cell physiology
- abnormal angiogenesis
- abnormal blood-brain barrier function
- abnormal bone marrow cell physiology
- abnormal chemokine level
- abnormal circulating aspartate transaminase level
- abnormal cytokine secretion
- abnormal dendritic cell physiology
- abnormal hematopoietic stem cell morphology
- abnormal impulse conducting system conduction
- abnormal induced retinal neovascularization
- abnormal intestinal goblet cell morphology
- abnormal leukocyte morphology
- abnormal long bone epiphyseal plate morphology
- abnormal long bone hypertrophic chondrocyte zone
- abnormal megakaryocyte differentiation
- abnormal metatarsal bone morphology
- abnormal myelination
- abnormal myocardial fiber physiology
- abnormal neutrophil physiology
- abnormal physiological neovascularization
- abnormal response to infection
- abnormal response/metabolism to endogenous compounds
- abnormal retinal apoptosis
- abnormal tibia morphology
- abnormal trabecular bone morphology
- abnormal tumor morphology
- abnormal vascular smooth muscle physiology
- abnormal vascular wound healing
- altered response to myocardial infarction
- aortic aneurysm
- cardiac fibrosis
- decreased IgE level
- decreased cardiac muscle contractility
- decreased circulating interleukin-10 level
- decreased dendritic cell number
- decreased histamine level
- decreased inflammatory response
- decreased interferon-gamma secretion
- decreased length of long bones
- decreased litter size
- decreased metastatic potential
- decreased myocardial infarction size
- decreased neuron apoptosis
- decreased oligodendrocyte number
- decreased physiological sensitivity to xenobiotic
- decreased sensitivity to xenobiotic induced morbidity/mortality
- decreased susceptibility to Flaviviridae infection
- decreased susceptibility to Flaviviridae infection induced morbidity/mortality
- decreased susceptibility to bacterial infection
- decreased susceptibility to experimental autoimmune encephalomyelitis
- decreased susceptibility to induced arthritis
- decreased susceptibility to induced colitis
- decreased susceptibility to injury
- decreased susceptibility to ischemic brain injury
- decreased tumor incidence
- delayed bone ossification
- delayed wound healing
- hypoalgesia
- impaired contextual conditioning behavior
- impaired hematopoiesis
- impaired myelopoiesis
- increased IgE level
- increased T cell proliferation
- increased T-helper 2 cell number
- increased angiogenesis
- increased body weight
- increased circulating interferon-beta level
- increased circulating interferon-gamma level
- increased eosinophil cell number
- increased interferon-gamma secretion
- increased interleukin-13 secretion
- increased interleukin-4 secretion
- increased interleukin-5 secretion
- increased lymphocyte cell number
- increased macrophage cell number
- increased monocyte cell number
- increased prostaglandin level
- increased sensitivity to xenobiotic induced morbidity/mortality
- increased susceptibility to Picornaviridae infection
- increased susceptibility to Picornaviridae infection induced morbidity/mortality
- increased susceptibility to dystrophic cardiac calcinosis
- increased susceptibility to type IV hypersensitivity reaction
- increased tibialis anterior weight
- increased vascular permeability
- increased ventricle muscle contractility
- increased width of hypertrophic chondrocyte zone
- joint inflammation
- joint swelling
- lung inflammation
- myocarditis
- osteopetrosis
- reduced fertility
- reduced long term potentiation
- short femur
- thick interventricular septum
- thick ventricular wall
role in cell
- invasion
- migration
- expression in
- phosphorylation in
- proliferation
- cell death
- upregulation in
- accumulation in
- apoptosis
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- soluble fraction
- glutaminergic synapse
- ficolin-1-rich granule lumen
- organelle
- Cytoplasm
- invadopodia
- cell surface
- intracellular space
- apical compartment
- perinuclear region
- organelle lumens
- cellular membrane
- Nucleus
- Plasma Membrane
- membrane compartment
- cytosol
- basal membrane
- perinuclear space
- neurites
- synaptosomes
- synapse
- gelatinase granules
- transport vesicles
- secretory vesicles
- extracellular matrix
- cellular protrusions
- cell membrane leading edge
- perikaryon
- dendrites
- postsynaptic density
- excitatory synapses
- exosomes
- plasma
- basement membrane
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mmp9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of epidermal growth factor receptor signaling pathway
- positive regulation of DNA binding
- cellular response to UV-A
- skeletal system development
- apoptotic process
- cellular response to cadmium ion
- negative regulation of epithelial cell differentiation involved in kidney development
- positive regulation of keratinocyte migration
- negative regulation of intrinsic apoptotic signaling pathway
- cell migration
- macrophage differentiation
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
- extracellular matrix disassembly
- positive regulation of receptor binding
- positive regulation of release of cytochrome c from mitochondria
- embryo implantation
- cellular response to lipopolysaccharide
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- proteolysis
- ephrin receptor signaling pathway
- positive regulation of protein phosphorylation
- extracellular matrix organization
- endodermal cell differentiation
- negative regulation of cation channel activity
- collagen catabolic process
- cellular response to reactive oxygen species
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- identical protein binding
- protein binding
- collagen binding
- serine-type endopeptidase activity
- endopeptidase activity
- peptidase activity
- metalloendopeptidase activity
- metallopeptidase activity