Vps11

Predicted to enable several functions, including protein domain specific binding activity; syntaxin binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of intracellular estrogen receptor signaling pathway; positive regulation of early endosome to late endosome transport; and vesicle organization. Located in actin filament and early endosome. Part of AP-3 adaptor complex and CORVET complex. Is active in presynaptic active zone. Human ortholog(s) of this gene implicated in dystonia 32 and hypomyelinating leukodystrophy 12. Orthologous to human VPS11 (VPS11 core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vps11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Vps11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Vps11 gene, providing context for its role in the cell.