Trim72 Gene Summary [Mouse]
Enables phosphatidylserine binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin protein ligase activity. Involved in several processes, including muscle organ development; plasma membrane repair; and protein homooligomerization. Acts upstream of or within negative regulation of myotube differentiation; negative regulation of signal transduction; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytoplasmic vesicle membrane and sarcolemma. Is expressed in heart and skeletal muscle. Orthologous to human TRIM72 (tripartite motif containing 72). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trim72 |
| Official Name | tripartite motif-containing 72 [Source:MGI Symbol;Acc:MGI:3612190] |
| Ensembl ID | ENSMUSG00000042828 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 72 |
| Synonyms | MG53, RGD1562778, tripartite motif-containing 72 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trim72 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- protein kinase binding
- SPRY domain
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- enzyme binding
- enzyme
- Ring finger domain
- protein binding
- identical protein binding
- associated with SPRY domains
- B-box-type zinc finger superfamily
- binding protein
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- B-box zinc finger
- TRIM domain
- SPRY-associated domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- neoplasia
- metabolic syndrome X
- centronuclear myopathy
- heart failure
- insulin resistance
- motor dysfunction or movement disorder
- reperfusion injury
- obesity
- hypertension
role in cell
- expression in
- activation in
- migration
- proliferation
- formation
- degradation in
- apoptosis
- cell viability
- damage
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic vesicle membrane
- cellular membrane
- Plasma Membrane
- vesicles
- sarcolemma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trim72 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- proteasomal ubiquitin-dependent protein catabolic process
- plasma membrane repair
- protein homooligomerization
- negative regulation of myotube differentiation
- muscle system process
- exocytosis
- negative regulation of insulin receptor signaling pathway
- negative regulation of insulin-like growth factor receptor signaling pathway
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- cytoplasm
- sarcolemma
Molecular Function
What the gene product does at the molecular level
- ubiquitin conjugating enzyme binding
- identical protein binding
- zinc ion binding
- phosphatidylserine binding
- protein binding
- mitogen-activated protein kinase kinase kinase binding